Shift Work, Heredity, Insulin, and Food Timing Study (SHIFT)
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The purpose of this study is to determine whether night time eating that coincides with elevated endogenous melatonin impairs glucose tolerance, particularly in carriers of the MTNR1B risk allele.
Condition or disease
Shift Work Type Circadian Rhythm Sleep DisorderDiabetes Mellitus, Type 2Circadian Rhythm Sleep Disorder, Shift Work TypeInsulin Resistance
Preliminary observations suggest that food intake coincident with high melatonin levels leads to impaired glucose tolerance—particularly in MTNR1B risk allele carriers. Our objectives are to determine the effect of concurrent food intake and melatonin on glucose tolerance; and to assess the role of MTNR1B single nucleotide polymorphism (SNP)*melatonin interaction in this deleterious effect. Our central hypothesis is that concurrent high melatonin levels and food intake, commonly experienced in night shift workers, cause long-term impairment of glucose tolerance and that this effect is worse in carriers of the MTNR1B type 2 diabetes (T2D) risk SNP than in non-carriers. The results of this proposal will help to clarify an ongoing controversy about the role of melatonin in glucose tolerance, and will help to develop novel strategies in the prevention and treatment of T2D, especially in shift workers, night eaters, and MTNR1B risk allele carriers.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Subjects residing in New England (USA) region
Male or non-pregnant female
Currently employed (night shift workers and day workers), graduate students, part-time workers, or unemployed
Able and willing to give consent relevant to genetic investigation
Currently taking any medications for the treatment of diabetes
Currently taking medications known to affect glycemic parameters, such as glucocorticoids, growth hormone or fluoroquinolones
Pregnant, nursing or at risk of becoming pregnant
Chronic renal failure, hepatic diseases, or cancer diagnoses
Bulimia diagnosis, prone to binge eating
Eating disorder diagnosis such as anorexia, binge eating, or bulimia
With psychiatric illness, such as schizophrenia or bipolar affective disorder