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Amino Acid Balance During Physical Inactivity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02980952
Recruitment Status : Completed
First Posted : December 2, 2016
Last Update Posted : October 25, 2018
Sponsor:
Information provided by (Responsible Party):
University of Exeter

Brief Summary:
The aim is to assess the impact of physical inactivity on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding will modulate muscle amino acid balance and forearm glucose uptake.

Condition or disease Intervention/treatment Phase
Assessing Muscle Amino Acid Balance Other: High-fat overfeeding Other: Forearm immobilization Not Applicable

Detailed Description:
The aim is to assess the impact of forearm cast immobilization on muscle amino acid balance and forearm glucose uptake. In addition, we will evaluate how high-fat overfeeding during immobilization will modulate muscle amino acid balance and forearm glucose uptake.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Amino Acid Balance During Physical Inactivity
Actual Study Start Date : January 2017
Actual Primary Completion Date : September 2018
Actual Study Completion Date : September 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Placebo Comparator: Energy-balanced diet
Forearm immobilization whilst consuming an energy-balanced diet
Other: Forearm immobilization
Experimental: High-fat overfeeding
Forearm immobilization whilst consuming a high-fat diet, 50% energy excess
Other: High-fat overfeeding
Other: Forearm immobilization



Primary Outcome Measures :
  1. Muscle amino acid balance [ Time Frame: 3 hours ]
    Forearm muscle amino acid balance


Secondary Outcome Measures :
  1. Glucose uptake [ Time Frame: 3 hours ]
    Forearm glucose uptake



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI between 18 and 30

Exclusion Criteria:

  • Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes).
  • Any diagnosed cardiovascular disease or hypertension.
  • Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140 mmHg over two or more measurements and an average diastolic blood pressure of ≥90 mmHg over two or more measurements.)
  • Chronic use of any prescribed or over the counter pharmaceuticals.
  • Regular use of nutritional supplements (e.g. creatine, protein supplementation)
  • Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).
  • A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.
  • Any previous motor disorders.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02980952


Sponsors and Collaborators
University of Exeter
Investigators
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Principal Investigator: Benjamin T Wall, PhD University of Exeter

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Responsible Party: University of Exeter
ClinicalTrials.gov Identifier: NCT02980952    
Other Study ID Numbers: 157758/03
First Posted: December 2, 2016    Key Record Dates
Last Update Posted: October 25, 2018
Last Verified: October 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No