Neuropathic Pain After Lung Surgery
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|ClinicalTrials.gov Identifier: NCT02960971|
Recruitment Status : Recruiting
First Posted : November 10, 2016
Last Update Posted : May 31, 2017
|Condition or disease||Intervention/treatment|
|Chronic Neuropathic Pain, Postoperative Chronic Pain, Postoperative Chronic Chemotherapy-induced Neuropathic Pain Chronic Chemotherapy-induced Pain Chronic Chemotherapy-induced Peripheral Neuropathy||Procedure: Thoracic surgery for lung cancer|
Pain and loss of function are intimately associated with the reaction of the nervous system to neural damage. A lesion to the somatosensory nervous system caused by mechanical trauma, metabolic disease, neurotoxic chemicals, infection or tumor invasion may give rise to neuropathic pain. Neuropathic pain affects around 8% of the population and may negatively impact the individual's quality of life; moreover, the condition leads to significant costs to the healthcare system and society. Not all subjects with such a lesion develop neuropathic pain, and those who do develop neuropathic pain have varying degrees of symptom severity, impact and outcomes and may respond unpredictably to treatment.
The interaction between genetics and environmental and clinical factors in a susceptible individual most likely contribute to the variation in pain prevalence and severity. A better understanding of the exact nature of these risk factors and their interactions will ultimately improve the patients' health, both in terms of recognizing patients at risk and identifying new treatment modalities.
Genetic, neurophysiological and psychological factors all influence the risk of developing persistent pain. It is therefore possible to describe a genetic, neurophysiological and psychological profile, in particular in patients experiencing neuropathic pain after surgery and/or neurotoxic chemotherapy.
|Study Type :||Observational|
|Estimated Enrollment :||275 participants|
|Official Title:||DOLORISK: Understanding Risk Factors and Determinants for Neuropathic Pain - Neuropathic Pain After Lung Surgery|
|Actual Study Start Date :||January 2, 2017|
|Estimated Primary Completion Date :||November 2019|
|Estimated Study Completion Date :||November 2019|
Procedure: Thoracic surgery for lung cancer
- Chronic Neuropathic Pain, Postoperative [ Time Frame: 12 months after surgery ]Neuropathic pain grading system, Finnerup et al. 2016 will be used.
- Chronic Chemotherapy-induced Peripheral Neuropathy [ Time Frame: 12 months after surgery ]For case definition of neuropathy, Tesfaye et al. 2010 will be used.
- Chronic Chemotherapy-induced Neuropathic Pain [ Time Frame: 12 months after surgery ]Neuropathic pain grading system, Finnerup et al. 2016 will be used.
- Acute Postoperative Pain [ Time Frame: 0-5 days after surgery ]Rest and movement-evoked postoperative pain measured on an 11-point NRS
- Area of peri-incisional hyperalgesia [ Time Frame: 0-5 days after surgery ]Quantification of peri-incisional hyperalgesia - area and worst pin-prick pain intensity is assessed with a 5.88 monofilament
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02960971
|Contact: Kasper Grosen, PhD||78463287 ext email@example.com|
|Contact: Pernille B Andersen, MHSc||78453156 ext firstname.lastname@example.org|
|Danish Pain Research Center, Aarhus University Hospital||Recruiting|
|Aarhus C, Denmark, 8000|
|Contact: Kasper Grosen, PhD 78463287 ext 45 email@example.com|
|Contact: Helle O Andersen 78463380 ext 45 firstname.lastname@example.org|
|Principal Investigator: Kasper Grosen, PhD|
|Sub-Investigator: Nanna B Finnerup, DMSc|
|Sub-Investigator: Lone Nikolajsen, DMSc|
|Sub-Investigator: Kristine J Bennedsgaard, MD|
|Sub-Investigator: Lise Ventzel, PhD|
|Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital||Recruiting|
|Aarhus N, Denmark, 8200|
|Contact: Pernille B Andersen, MHSc 78453156 ext 45 email@example.com|
|Contact: Vibeke E Hjortdal, DMSc 78450000 ext 45 firstname.lastname@example.org|
|Sub-Investigator: Vibeke E Hjortdal, DMSc|
|Study Director:||Nanna B Finnerup, DMSc||Danish Pain Research Center, Aarhus University|