Measuring the Metabolic Cost of Fever (IGUANA)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02939781|
Recruitment Status : Unknown
Verified October 2016 by Great Ormond Street Hospital for Children NHS Foundation Trust.
Recruitment status was: Not yet recruiting
First Posted : October 20, 2016
Last Update Posted : October 20, 2016
Fever is part of the body's immune response, often triggered by infection. Fever is commonly treated with medicines such as paracetamol, mainly because people feel unwell with fever. However fever does have a role in fighting infection: it enables the rest of the immune system to function more efficiently, and may directly stop bacteria and viruses from multiplying. In most cases however treating fever does not matter because the rest of the immune system can cope well enough to fight the infection (with or without additional treatment, like antibiotics).
In critically ill patients however any advantage in the fight against infection may be crucial. In a large observational study of adult patients in the intensive care unit, patients who developed an early fever with temperature between 38.5-39.5 degrees C fared relatively better than patients who were colder. So it is possible that in critical illness fever may be beneficial. However in critical illness the body does have limited energy resources. In order to raise the body temperature energy is required. However the investigators do not know how much energy is required to generate a fever in critically ill children. This study will aim to try and measure the energy required to generate a fever in a critically ill child. The investigators will measure energy expenditure directly in children admitted to the intensive care unit by measuring the levels of oxygen and carbon dioxide they breathe in and out (a method called indirect calorimetry). This will enable the investigators to judge whether the benefits of a fever can be justified by the energy costs in the energy depleted state that is critical illness.
|Condition or disease||Intervention/treatment|
|Child Critical Illness Fever||Device: Indirect calorimetry|
|Study Type :||Observational|
|Estimated Enrollment :||15 participants|
|Official Title:||Measuring Energy Expenditure Before and After Fever in Critically Ill Children|
|Study Start Date :||November 2016|
|Estimated Primary Completion Date :||November 2017|
Febrile critically ill children
Children above 10kg admitted to the paediatric intensive care unit at Great Ormond Street Hospital who are mechanically ventilated and have a high likelihood of developing a fever. Energy expenditure will be measured using indirect calorimetry at baseline, and continuously during fever, until fever subsides.
Device: Indirect calorimetry
Indirect calorimetry measurement at baseline (stable state), at onset of fever and continued till fever dehiscence
- Change in energy expenditure (in kcal) before, during and after fever [ Time Frame: 6 hours ]Children at risk of fever will have energy expenditure measured by indirect calorimetry at baseline, when the develop a fever, and continuously until fever dehisces.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02939781
|Contact: Samiran Ray, MBBChir MA||02074059200 ext email@example.com|
|Principal Investigator:||Mark J Peters, MBBCh PhD||UCL Great Ormond Street Institute of Child Health|