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The Effect of Isokinetic Strengthening Training

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ClinicalTrials.gov Identifier: NCT02938416
Recruitment Status : Active, not recruiting
First Posted : October 19, 2016
Last Update Posted : April 24, 2018
Sponsor:
Information provided by (Responsible Party):
Yuan-Yang Cheng, Taichung Veterans General Hospital

Brief Summary:
Our participants will include 40 patients within one month of stroke, 40 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to the isokinetic training group or the isotonic training group. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the improvement of outcome measures of the isokinetic and the isotonic training groups.

Condition or disease Intervention/treatment Phase
Resistance Training Stroke Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Device: Isokinetic strengthening exercise Device: Isotonic strengthening exercise Not Applicable

Detailed Description:
Our participants will include 40 patients within one month of stroke, 40 patients who received total hip replacement or total knee replacement two to four weeks before. The participants will be randomly assigned to the isokinetic training group or the isotonic training group. Outcome measures including isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s, Short Form 36 (SF-36), the Timed Up and Go test, the Oxford Hip/knee Score, the plasma concentration of hsCRP, and the level of substance P in saliva will be collected at the beginning and 4 weeks after the training program. Statistical significant differences will be determined between the

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Comparison of the Functional Recovery and Cytokines Changes Between Isokinetic and Isotonic Training in Patients With Acute Stroke, After Total Hip Replacement or After Total Knee Replacement
Study Start Date : January 2013
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Hip Replacement

Arm Intervention/treatment
Experimental: Isokinetic training
Ten times, three sets of isokinetic strengthening exercise using 30 degree/sec and 120 degree/sec
Device: Isokinetic strengthening exercise
Isokinetic strengthening exercise provides muscle training throughout the range of motion of a joint at a pre-set constant speed of angular velocity. It can be performed in an eccentric or concentric way in a controlled manner, and is evidenced to be an effective and safe training method in patients with anterior cruciate ligament reconstruction, burn injury, ankle instability, osteoarthritic knee, and chronic stroke in the past literatures.

Active Comparator: Isotonic training
Ten times, three sets of isotonic strengthening exercise using consistent resistance of 60% of 1-repetition maximum of hip or knee
Device: Isotonic strengthening exercise
Isotonic strengthening exercise keeps the tension remained unchanged during the muscle's length changing. As the muscle's force changes via the length-tension relationship during a contraction, an isotonic contraction will keep force constant while velocity changes. There are two types of isotonic contractions: (1) concentric and (2) eccentric. In a concentric contraction, the muscle tension rises to meet the resistance, then remains the same as the muscle shortens. In eccentric, the muscle lengthens due to the resistance being greater than the force the muscle is producing.




Primary Outcome Measures :
  1. Peak torque [ Time Frame: 4 weeks ]
    Isometric peak torque of hip/knee at 90 degree of flexion, peak torque of hip/knee at angular velocity of 60 degree/s and 120 degree/s


Secondary Outcome Measures :
  1. Timed Up and Go test [ Time Frame: 4 weeks ]
  2. Short Form 36 (SF-36) questionnaire [ Time Frame: 4 weeks ]
    Use the 36-item, patient-reported questionnaire to survey the self-perceived health status

  3. Oxford Hip/Knee Score [ Time Frame: 4 weeks ]
  4. The plasma concentration of hsCRP, and the level of substance P in saliva [ Time Frame: 4 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • within one month of acute stroke
  • receive total hip/knee replacement within two to four weeks before

Exclusion Criteria:

  • cannot perform from sitting to standing
  • Body Mass Index > 30
  • Lower limbs fracture history
  • Diabetic polyneuropathy
  • Cardiopulmonary diseases that impede exercise prescription
  • Impaired cognitive function
  • Infectious disease during the study period that may cause cytokine changes

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02938416


Locations
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Taiwan
Department of Physical Medicine and Rehabilitation
Taichung City, Taiwan, 40705
Sponsors and Collaborators
Taichung Veterans General Hospital
Investigators
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Principal Investigator: Yuan-Yang Cheng, MD, PhD Department of Physical Medicine and Rehabilitation

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Responsible Party: Yuan-Yang Cheng, Visiting Staff Doctor, Taichung Veterans General Hospital
ClinicalTrials.gov Identifier: NCT02938416     History of Changes
Other Study ID Numbers: CF12251
First Posted: October 19, 2016    Key Record Dates
Last Update Posted: April 24, 2018
Last Verified: April 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
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Stroke
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases