Working...
ClinicalTrials.gov
ClinicalTrials.gov Menu

Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise (OPEX)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02938117
Recruitment Status : Not yet recruiting
First Posted : October 19, 2016
Last Update Posted : October 19, 2016
Sponsor:
Information provided by (Responsible Party):
University Hospital, Clermont-Ferrand

Brief Summary:

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition


Condition or disease Intervention/treatment Phase
Adults BMI>35 Other: cycling exercises Not Applicable

Detailed Description:
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 30 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Official Title: Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise
Study Start Date : January 2017
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : January 2020

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: CON : concentric cycling exercise
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise
Other: cycling exercises
Experimental: EXC : eccentric cycling exercise
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise
Other: cycling exercises



Primary Outcome Measures :
  1. change in total body fat mass (Dual X ray Absorptiometry) [ Time Frame: before and after the 12 weeks training program ]

Secondary Outcome Measures :
  1. aerobic capacities (VO2max) [ Time Frame: before and after the 12 weeks training program ]
  2. isometric muscular lower limbs strength [ Time Frame: before and after the 12 weeks training program ]
  3. isokinetic muscular lower limbs strength [ Time Frame: before and after the 12 weeks training program ]
  4. rest energy expenditure (indirect calorimetry) [ Time Frame: before and after the 12 weeks training program ]
  5. biological parameters (plasma lipid profile) [ Time Frame: before and after the 12 weeks training program ]
  6. biological parameters (insulin-resistance) [ Time Frame: before and after the 12 weeks training program ]
  7. physical activity [ Time Frame: before and after the 12 weeks training program ]
    (questionnaires)

  8. physical activity [ Time Frame: before and after the 12 weeks training program ]
    (actimetry)

  9. food intakes [ Time Frame: before and after the 12 weeks training program ]
    (measurements)

  10. food intakes [ Time Frame: before and after the 12 weeks training program ]
    (questionnaires)

  11. quality of life (questionnaires) [ Time Frame: before and after the 12 weeks training program ]
  12. segmental body composition [ Time Frame: before and after the 12 weeks training program ]
    (segmental fat and fat free mass)



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • - Adults
  • Obese (BMI>35)
  • Inactive (<10 METS/h/week)
  • No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria:

  • (BMI<35)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02938117


Contacts
Layout table for location contacts
Contact: Patrick LACARIN 04 73 75 11 95 placarin@chu-clermontferrand.fr

Locations
Layout table for location information
France
CHU Clermont-Ferrand Not yet recruiting
Clermont-Ferrand, France, 63003
Contact: Patrick LACARIN    04 73 75 11 95    placarin@chu-clermontferrand.fr   
Principal Investigator: Valérie JULIAN         
Sponsors and Collaborators
University Hospital, Clermont-Ferrand
Investigators
Layout table for investigator information
Principal Investigator: Valérie JULIAN University Hospital, Clermont-Ferrand

Layout table for additonal information
Responsible Party: University Hospital, Clermont-Ferrand
ClinicalTrials.gov Identifier: NCT02938117     History of Changes
Other Study ID Numbers: CHU-0284
2016-A01185-46 ( Other Identifier: 2016-A01185-46 )
First Posted: October 19, 2016    Key Record Dates
Last Update Posted: October 19, 2016
Last Verified: October 2016

Keywords provided by University Hospital, Clermont-Ferrand:
obesity
eccentric exercise
body composition
training program

Additional relevant MeSH terms:
Layout table for MeSH terms
Overweight
Body Weight
Signs and Symptoms