COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC:

Get the latest research information from NIH: Menu

Intranasal Desmopressin vs IV Ketorolac in Renal Colic Pain Control

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02937896
Recruitment Status : Completed
First Posted : October 19, 2016
Last Update Posted : October 19, 2016
Information provided by (Responsible Party):
Kambiz Nasiri, Shahid Beheshti University of Medical Sciences

Brief Summary:
The aim of this study is the comparison of efficacy of intravenous ketorolac and intranasal desmopressin in renal colic patients pain control.

Condition or disease Intervention/treatment Phase
Renal Colic Drug: Desmopressin Drug: Ketorolac Drug: Normal Saline Not Applicable

Detailed Description:
40 renal colic patients have been divided into 2 groups randomly, one group has been received 30mg intravenous Ketorolac and 4 puffs nasal Normal Saline while other has been received 40 micrograms nasal Desmopressin and 1cc intravenous Normal Saline. Pain Score before drug administration,also 10, 30 and 60 minutes after drug administration has been measured bye Visual Analogue Scale ( VAS ).

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: Comparison of Intranasal Desmopressin vs IV Ketorolac in Renal Colic Patients
Study Start Date : January 2015
Actual Primary Completion Date : February 2016
Actual Study Completion Date : April 2016

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Ketorolac
30mg ketorolac administrated intravenous and 4 puffs nasal Normal Saline.
Drug: Ketorolac
30mg intravenous Ketorolac.
Other Name: Toradol

Drug: Normal Saline
4 puffs nasal Normal Saline.
Other Name: NaCl

Active Comparator: Desmopressin
40 microgram nasal desmopressin administrated and 1cc Normal Saline intravenous
Drug: Desmopressin
40 micrograms Nasal Desmopressin.
Other Name: Ddavp

Drug: Normal Saline
1cc intravenous Normal Saline.
Other Name: NaCl

Primary Outcome Measures :
  1. Pain score [ Time Frame: Pain score change from baseline pain score before intervention 10, 30 and 60 minutes after intervention ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   16 Years to 50 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • renal colic patients

Exclusion Criteria:

  • history of hypertension and cardiac disease
  • pregnant patients
  • use of analgesic within 4 hours before intervention
Layout table for additonal information
Responsible Party: Kambiz Nasiri, Emergency Medicine Resident, Shahid Beheshti University of Medical Sciences Identifier: NCT02937896    
Other Study ID Numbers: 688
First Posted: October 19, 2016    Key Record Dates
Last Update Posted: October 19, 2016
Last Verified: October 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Additional relevant MeSH terms:
Layout table for MeSH terms
Renal Colic
Infant, Newborn, Diseases
Neurologic Manifestations
Deamino Arginine Vasopressin
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antidiuretic Agents
Natriuretic Agents