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Compare Train and 3D-4D Left Ventricular Systolic Function in Subjects Suffering From Dystrophy and Healthy Subjects

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02930408
Recruitment Status : Terminated
First Posted : October 12, 2016
Last Update Posted : October 12, 2016
Information provided by (Responsible Party):
Poitiers University Hospital

Brief Summary:
Steinert's disease is an orphan disease. The prognosis of patients with this disease is conditioned by cardiac involvement. Search an early stage alterations in contractile function in subjects suffering from dystrophy would detect patients at risk of sudden death. The first stage of work is to validate the tools to detect early stage of infringement systolic function in a population of patients with myotonic dystrophy.

Condition or disease Intervention/treatment Phase
Steinert's Disease Procedure: electrocardiogram Procedure: Echocardiography Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 70 participants
Study Start Date : January 2014
Actual Primary Completion Date : July 2015

Primary Outcome Measures :
  1. Ventricular Ejection Fraction Left 3D [ Time Frame: Immediately ]
  2. Global longitudinal systolic Strain [ Time Frame: Immediately ]
  3. Strain of the dispersion index [ Time Frame: Immediately ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • patients suffering from muscular dystrophy type 1 followed CHU Poitiers.
  • age ≥ 18 years

Exclusion Criteria:

  • duration QRS> 120 ms ECG permanent ventricular stimulation
  • trouble segmental kinetic obvious to echocardiography in visual analysis

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Responsible Party: Poitiers University Hospital Identifier: NCT02930408    
Other Study ID Numbers: STEINECHO
First Posted: October 12, 2016    Key Record Dates
Last Update Posted: October 12, 2016
Last Verified: August 2016
Additional relevant MeSH terms:
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Myotonic Dystrophy
Muscular Dystrophies
Myotonic Disorders
Muscular Disorders, Atrophic
Muscular Diseases
Musculoskeletal Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Nervous System Diseases
Neuromuscular Diseases
Genetic Diseases, Inborn