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Association of Snowfall and Myocardial Infarction

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02913820
Recruitment Status : Completed
First Posted : September 26, 2016
Last Update Posted : January 10, 2018
Sponsor:
Information provided by (Responsible Party):
Medical University of Graz

Brief Summary:
Changes in the ambient temperature (esp. warm to cold) as well as exercise are triggers for vasospasms and plaque rupture. Weather data (temperature, precipitation in general as well as snowfall and changes in atmospheric pressure) will be correlated with the incidence of myocardial infarctions.

Condition or disease Intervention/treatment
Acute Myocardial Infarction Other: snowfall > 5cm/day

Detailed Description:

Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of air temperature (changes) or humidity are of potential relevance. In addition, exercise and the associated increase in oxygen demand of the myocardium and blood pressure is another trigger for plaque rupture and the acute onset of myocardial infarction. Male patients as well as patients with previous coronary heart disease or little regular exercise are at increased risk.

Possible additional mechanisms of exercise induced myocardial infarction are vasospasm and changes in blood clotting.

Changes in the ambient temperature (warm to cold) can also induce vasospasm which might result in reduced perfusion and plaque rupture. It seems that male patients are more involved than female patients.

Taking the exercise and the ambient temperature changes into consideration, heavy snowfall with consecutive snow shoveling is an augmented risk for acute myocardial infarction.

The rationale of the study is to test if the above mentioned constellation of environmental factors as well as potential increased exercise have a significant and independent impact on the incidence of myocardial infarctions

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Study Type : Observational
Actual Enrollment : 18075 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Association of Snowfall and Myocardial Infarction
Study Start Date : January 2007
Actual Primary Completion Date : June 30, 2017
Actual Study Completion Date : June 30, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Group/Cohort Intervention/treatment
snowfall >5cm/d
impact of snowfall and its correlation with acute myocardial infarctions is analyzed. Other precipitation (rainfall) changes in atmospheric pressure and temperature will be variables to be corrected for.
Other: snowfall > 5cm/day
the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of snowfall




Primary Outcome Measures :
  1. myocardial infarction [ Time Frame: 1 day ]
    the number of myocardial infarctions of every day analysed in this study will be correlated with the respective values of snowfall



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Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients with myocardial infarction being transfered to a cath lab either at the medical university of Graz or the department of cardiology at the state hospital Graz West
Criteria

Inclusion Criteria:

  • myocardial infarction being confirmed or treated in the cathlab

Exclusion Criteria:

  • none

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02913820


Locations
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Austria
Medical University of Graz
Graz, Austria, 8010
Sponsors and Collaborators
Medical University of Graz
Publications of Results:

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Responsible Party: Medical University of Graz
ClinicalTrials.gov Identifier: NCT02913820    
Other Study ID Numbers: EK28-433ex15/16
First Posted: September 26, 2016    Key Record Dates
Last Update Posted: January 10, 2018
Last Verified: January 2018
Additional relevant MeSH terms:
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Myocardial Infarction
Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases