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The first aim of the study is to obtain from chirurgical micro biopsy myoblast in culture which will differentiate in Diaphragm fiber. Then these fibers will be submitted under mechanical stress condition similar to those imposed in vivo by mechanical ventilation to validate in human a model in vitro of diaphragm dysfunction induced by mechanical ventilation. Then the second part of the study will be to evaluate with this model, the efficiency of an antioxidant therapy.
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Layout table for eligibility information
Ages Eligible for Study:
45 Years to 70 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patient who benefeciat of a thoracotomy for local pulmonary resection in regard to a lung cancer.
Patient who will undergo a surgery for a localised broncho-pulmonary tumor (stade 1A), and have stopped to smoke since more than 6 month and clinically stable.
Patients with neuro-muscular disorder, heart desease, chronic obtructive pulmonary disease, metabolic disorder or infection.