Variations in Retinal Nerve Fiber Layer Thickness During Uncomplicated Anterior and Intermediate Uveitis
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This study investigates the variations in the retinal nerve fiber layer (RNFL) thickness during uncomplicated anterior and intermediate uveitis, respectively. The objectives are to 1 ) confirm the RNFL thickening during an uncomplicated anterior uveitis as described in the literature, 2) measure the RNFL thickness during an uncomplicated intermediate uveitis specifically and 3) describe the variation in time of RNFL thickness during the two types of uveitis.
Condition or disease
Anterior UveitisIntermediate Uveitis
Thirty six individuals (18 with anterior uveitis and 18 with intermediate uveitis) will be recruited at the Centre universitaire d'ophtalmologie du CHU de Québec. RNFL thickness will be measured with optical coherence tomography at 3 times. For anterior uveitis, the RNFL thickness will be measured at presentation, 1 week and 4 to 6 weeks. For intermediate uveitis, the RNFL thickness will be measured at presentation, 4 to 6 weeks and 4 months. The initial thickness will be studied for each type of uveitis and progression over time will be studied also for each type of uveitis.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Adult of 18 years old or more with anterior or intermediate uncomplicated uveitis
18 years old or more
anterior uncomplicated uveitis or intermediate uncomplicated uveitis
history of uveitis in the past, other than the actual uveitis
history of ophthalmologic pathology with potential impact on retinal nerve fiber layer thickness
optic nerve or macular clinically apparent edema
history of glaucoma or other optic neuropathy
suspected or confirmed multiple sclerosis
ocular hypertension (intraocular pressure more than 22 mmHg)
reduced optical coherence tomography signal (lower than 7) on the Cirrus HD-OCT