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The Effect of Breaking Prolonged Sitting on Adipose Tissue and Metabolism

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ClinicalTrials.gov Identifier: NCT02870088
Recruitment Status : Completed
First Posted : August 17, 2016
Last Update Posted : August 17, 2016
Sponsor:
Collaborator:
Ministry of Education, Taiwan
Information provided by (Responsible Party):
Yung-Chih Chen, University of Bath

Brief Summary:
The purpose of this project is to investigate the effect of breaking prolonged sitting on acute adipose tissue and metabolic responses.

Condition or disease Intervention/treatment Phase
Insulin Sensitivity Behavioral: Prolonged Sitting Behavioral: Breaking Sitting Not Applicable

  Show Detailed Description

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 11 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Study Start Date : July 2014
Actual Primary Completion Date : January 2016
Actual Study Completion Date : January 2016

Arm Intervention/treatment
Active Comparator: Prolonged Sitting
Participants sat on a chair during the trial.
Behavioral: Prolonged Sitting
After consuming 1st meal, participants sat on a chair for 180 min. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants sat on a chair for another 120 min.

Experimental: Breaking Sitting
Participants walked regularly during the trial.
Behavioral: Breaking Sitting
After consuming 1st meal, participants walked 2 min on a treadmill every 20 minutes for the following 180 min. For the remainder of the time participants sat on the chair. After 180 min, the 2nd meal was provided. After finishing the 2nd meal, participants continued 2 min of walking every 20 min for the following 120 min.




Primary Outcome Measures :
  1. Incremental area under curve (iAUC) for insulin [ Time Frame: 330 minutes ]

Secondary Outcome Measures :
  1. Changes in gene expression in the adipose tissue [ Time Frame: Before the 1st meal and 120 min after the 2nd meal (330 minutes). ]
  2. Changes in insulin, glucose, TAG and NEFA in blood [ Time Frame: 330 minutes ]
  3. Changes in serum Interleukin-6 (IL-6), leptin and adiponectin [ Time Frame: 330 minutes ]
  4. Changes in Interleukin-6 (IL-6), leptin and adiponectin protein secretion from adipose tissue explants [ Time Frame: Before the 1st meal and 120 min after the 2nd meal (330 minutes). ]


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Ages Eligible for Study:   35 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male and post-menopausal females (post-menopausal diagnosis based on consecutive absence of menstrual cycles for >12 months).
  • Aged between 35 and 64 years
  • Central overweight (waist circumference greater than 94 cm for males and 80 cm for females)
  • Weight stable for more than 3 months (no change in weight +/- 3%)
  • Non-smoker
  • Able to walk comfortably on a treadmill

Exclusion Criteria:

  • Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
  • Waist circumference < 94cm for male and < 80cm for female
  • Taking medications that may influence lipid or carbohydrate metabolism or immune system function
  • Unable to take part in exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)

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Responsible Party: Yung-Chih Chen, PhD student, University of Bath
ClinicalTrials.gov Identifier: NCT02870088     History of Changes
Other Study ID Numbers: 13/SW/0321
First Posted: August 17, 2016    Key Record Dates
Last Update Posted: August 17, 2016
Last Verified: August 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Additional relevant MeSH terms:
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Insulin Resistance
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases