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Trial record 31 of 668 for:    CARBON DIOXIDE AND arterial

GapCO2 and Respiratory Rate in Patients Under Volume Mechanical Ventilation (gapCO2)

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ClinicalTrials.gov Identifier: NCT02867943
Recruitment Status : Unknown
Verified August 2016 by 105 Hospital of Chinese People's Liberation Army.
Recruitment status was:  Active, not recruiting
First Posted : August 16, 2016
Last Update Posted : August 18, 2016
Sponsor:
Information provided by (Responsible Party):
105 Hospital of Chinese People's Liberation Army

Brief Summary:
As an approximate of the difference between venous-to-arterial CO2 tension (∆PCO2), ∆PCO2 is proportional to CO2 production and inversely related to cardiac output (Fick equation). Anaerobic CO2 production is thought to occur when tissue hypoxia is present, mostly because of buffering of bicarbonate ions by the protons produced in excess secondary to the hydrolysis of adenosine triphosphate. Therefore ∆PCO2 has been proposed as a marker of tissue hypoxia.

Condition or disease Intervention/treatment
Shock Other: Effects of respiratory rate on gapCO2

Detailed Description:

An increased ∆PCO2 (> 6 mmHg) could be used to identify patients who still remain inadequately resuscitated, when deciding when to continue resuscitation despite a central venous oxygen saturation (ScvO2) > 70% associated with elevated blood lactate levels.

Under steady states of both VO2 and VCO2, P (v-a) CO2 was observed to increase in parallel with the reduction in cardiac output. However, spontaneous breathing and hyperventilation may reduce PaCO2 and prevent the CO2 stagnation-induced rise in PvCO2.

To date,these studies of ∆PCO2 and respiratory rate in septic shock patients Under Volume Mechanical Ventilation are rarely.


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Study Type : Observational
Estimated Enrollment : 28 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effects of Respiratory Rate on Venous-to-arterial CO2 Tension Difference in Septic Shock Patients Under Volume Mechanical Ventilation
Study Start Date : October 2015
Estimated Primary Completion Date : October 2016
Estimated Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Shock

Group/Cohort Intervention/treatment
respiratory rate is 10 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2;

Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2
respiratory rate was started at 10 breaths/min and added by 2 breaths/min every 60 min up to 16 breaths/min

respiratory rate is 12 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2;

Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2
respiratory rate was started at 10 breaths/min and added by 2 breaths/min every 60 min up to 16 breaths/min

respiratory rate is 14 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2;

Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2
respiratory rate was started at 10 breaths/min and added by 2 breaths/min every 60 min up to 16 breaths/min

respiratory rate is 16 breaths/min

GapCO2=Pv-aCO2 = PvCO2 - PaCO2;

Effects of venous-to-arterial CO2 tension difference after increased respiratory rate.

Other: Effects of respiratory rate on gapCO2
respiratory rate was started at 10 breaths/min and added by 2 breaths/min every 60 min up to 16 breaths/min




Primary Outcome Measures :
  1. Effects of respiratory rate on venous-to-arterial CO2 tension difference in septic shock patients Under Volume Mechanical Ventilation [ Time Frame: 1 year ]


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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
The subjects were sequentially admitted to the Department of Critical Care Medicine of 105 Hospital of PLA from March of 2016 till the end of this study.
Criteria

Inclusion Criteria:

Patients were included in the study, if the attending physician find the persistence of signs of hypoperfusion (oliguria, mottled skin, central venous oxygen saturation (ScvO2) <70 % despite a hemoglobin > 8 g/dl),despite achieving adequate intravascular volume and adequate mean arterial pressure (MAP) > 65 mmHg as recommended by the Surviving Sepsis Campaign.

Exclusion Criteria:

Exclusion criteria were pregnancy, COPD,age less than 18 years old, unstable hemodynamic condition (change of vasoactive drug dosage or fluid administration within 1 h preceding the protocol) and uncontrolled tachyarrhythmias (heart rate>140 beats/min).


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Responsible Party: 105 Hospital of Chinese People's Liberation Army
ClinicalTrials.gov Identifier: NCT02867943     History of Changes
Other Study ID Numbers: PLA-105-ICU
First Posted: August 16, 2016    Key Record Dates
Last Update Posted: August 18, 2016
Last Verified: August 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Keywords provided by 105 Hospital of Chinese People's Liberation Army:
sepsis, shock,Lactate,volume controlled ventilation
Additional relevant MeSH terms:
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Shock
Pathologic Processes