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Dose-response Effects of Soybean Oil in Salad Dressing on Carotenoid/Fat-soluble Vitamin Bioavailability in Salad Vegetables

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02867488
Recruitment Status : Completed
First Posted : August 16, 2016
Last Update Posted : August 18, 2016
Information provided by (Responsible Party):
Wendy S. White, Iowa State University

Brief Summary:
The objectives will be to evaluate the dose-response between the amount of soybean oil in salad dressing and the absorption of: 1) carotenoids, phylloquinone, and tocopherols in salad vegetables; 2) retinyl palmitate formed from the provitamin A carotenoids, alpha- and beta-carotene.

Condition or disease Intervention/treatment Phase
Biological Availability Other: Soybean oil in salad dressing Not Applicable

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Study Type : Interventional  (Clinical Trial)
Study Start Date : April 2009
Actual Primary Completion Date : November 2009
Actual Study Completion Date : June 2016

Resource links provided by the National Library of Medicine

Primary Outcome Measures :
  1. Area under the curve for carotenoids, phylloquinone, tocopherols, and retinyl palmitate in the plasma chylomicron fraction [ Time Frame: 0-9.5 hours postprandially ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • General good health as determined by interview, blood biochemistry profile, complete blood count, and plasma lipid and lipoprotein profile

Exclusion Criteria:

  • Cigarette smoking, frequent alcohol consumption
  • Use of vitamin/mineral supplements
  • Lactose intolerance
  • Known food allergies
  • Body mass index (BMI) 30 or higher
  • Eating disorder or restrained eating
  • Vegetarianism
  • Hyperlipidemia
  • Current or planned pregnancy
  • Use of hormonal contraceptives (affects chylomicron clearance); use of plant sterols or medications known to affect lipid metabolism
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Wendy S. White, Associate Professor, Iowa State University Identifier: NCT02867488    
Other Study ID Numbers: 08-549
First Posted: August 16, 2016    Key Record Dates
Last Update Posted: August 18, 2016
Last Verified: August 2016
Keywords provided by Wendy S. White, Iowa State University:
vitamin A