Transpulmonary Pressure and Airway Pressure Release Ventilation (APRV).
|ClinicalTrials.gov Identifier: NCT02866513|
Recruitment Status : Completed
First Posted : August 15, 2016
Last Update Posted : November 14, 2017
Mechanical ventilation can induce pulmonary lesions called ventilator induced lung injury (VILI). High levels of Transpulmonary pressure is one of the most important mechanism of VILI during the use of mechanical ventilation. The use of bilevel pressure ventilator modes like APRV could generate high levels of transpulmonary pressure.
The aim of this study is to evaluate the variations of transpulmonary pressure during the use of APRV by clinicians
|Condition or disease||Intervention/treatment||Phase|
|Patient Mechanically Ventilated With APRV Mode||Other: evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Incidence of High Levels of Transpulmonary Pressure During the Use of Airway Pressure Release Ventilation.|
|Actual Study Start Date :||February 2016|
|Actual Primary Completion Date :||December 2016|
|Actual Study Completion Date :||March 2017|
|Patient mechanically ventilated with APRV mode||
Other: evaluate the variations of transpulmonary pressure during the use of APRV by clinicians.
- Transpulmonary pressure [ Time Frame: 24 hours ]Measurement of transpulmonary pressure needs the measurement of oesophageal pressure with a specific nasogastric tube. This measurement is now available in routine in few mechanical ventilators in intensive care units (eg: AVEA Ventilator. Vyasys HealthCare). Transpulmonary pressure is the difference between airway pressure and oesophageal pressure and it is now easy to obtain and monitor at the bedside with these ventilators. It is also possible to record the value furthermore than 24 hours.
- Maximal value of transpulmonary pressure [ Time Frame: 24 hours ]Value of tidal volume > 8 ml/kg
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02866513
|Assistance Publique Hôpitaux de Marseille hôpital de la Timone|
|Marseille, France, 13354|
|Study Director:||Urielle DESALBRES||Assistance Publique Hôpitaux de Marseille|