Biological and Clinical Measurements Following Systemic Leakage When a Citrate or Heparin Lock is Used (VERROU HEMOST)
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
In the VERROUREA study, there were two cases of an abnormal increase in TCA. In theory no leakage of the lock into the bloodstream should have been seen. Lock leakage could have particularly serious, and especially clinical, repercussions in these patients who already have a high risk of haemorrhage given the numerous associated comorbidities. The aim of this study is to investigate the leakage of locks into the bloodstream by measuring, before and after injection of the lock, the evolution of haemostasis tests and calcaemia. The findings will complete safety data already collected in the VERROU REA study.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patient aged > 18 years
Requiring dialysis for acute kidney failure
In whom a first non-tunnelled catheter has been inserted
In the jugular or femoral position
Once informed consent has been obtained from the patient, a family member or a person of trust
Patients with active and poorly-controlled bleeding
Known allergy to citrate
Liver failure (Factor V <30%)
Thrombopenia < 30 000/mm3 in the absence of planned corrective measures at the time of randomization
Known or suspected heparin-induced thrombopenia
Positive blood cultures without treatment or with inappropriate treatment at the time of randomization