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Trial record 43 of 531 for:    Taste Disorders

Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease (Smell&Crohn)

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ClinicalTrials.gov Identifier: NCT02859675
Recruitment Status : Terminated (difficulties for patient enrolment)
First Posted : August 9, 2016
Last Update Posted : August 9, 2016
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire Dijon

Brief Summary:
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

Condition or disease Intervention/treatment
Crohn's Disease Olfactogustatory Perception Other: triangular test

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Study Type : Observational
Actual Enrollment : 1 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease
Study Start Date : October 2013
Actual Primary Completion Date : May 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Crohn's Disease

Group/Cohort Intervention/treatment
triangular test Other: triangular test



Primary Outcome Measures :
  1. Modification of sweet taste [ Time Frame: through the study completion up to 4 years ]
    the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

  2. Modification of salty taste [ Time Frame: through the study completion up to 4 years ]
    the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

  3. Modification of sour taste [ Time Frame: through the study completion up to 4 years ]
    the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

  4. Modification of bitter taste [ Time Frame: through the study completion up to 4 years ]
    the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

  5. Modification of umami taste [ Time Frame: through the study completion up to 4 years ]
    the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests



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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups
Criteria

Inclusion Criteria:

  • Age between 18 and 60 years,
  • Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
  • Crohn's disease in flare, defined by a Crohn's Disease Activity Index score (CDAI > 150),
  • Men or women who have provided consent and willing to cooperate.
  • Patients with national health insurance cover.

Exclusion Criteria:

  • Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
  • Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
  • Organ failure (respiratory, heart, or renal failure, neurological disorders),
  • Intolerance to gluten,
  • Treatments (other than those used for Crohn's disease) able to interfere with food intake,
  • Aversion to foods consumed or smelled,
  • Poor understanding of cognitive tasks required.
  • Crohn's disease complicated by an abscess or infectious complication

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02859675


Locations
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France
Centre Hospitalier Universitaire
Dijon, France, 21079
Sponsors and Collaborators
Centre Hospitalier Universitaire Dijon

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Responsible Party: Centre Hospitalier Universitaire Dijon
ClinicalTrials.gov Identifier: NCT02859675     History of Changes
Other Study ID Numbers: BRONDEL Ass INRA 2011
First Posted: August 9, 2016    Key Record Dates
Last Update Posted: August 9, 2016
Last Verified: June 2016

Additional relevant MeSH terms:
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Inflammation
Crohn Disease
Pathologic Processes
Inflammatory Bowel Diseases
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases