Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease (Smell&Crohn)
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ClinicalTrials.gov Identifier: NCT02859675
Recruitment Status :
(difficulties for patient enrolment)
This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 60 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups
Age between 18 and 60 years,
Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
Crohn's disease in flare, defined by a Crohn's Disease Activity Index score (CDAI > 150),
Men or women who have provided consent and willing to cooperate.
Patients with national health insurance cover.
Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
Organ failure (respiratory, heart, or renal failure, neurological disorders),
Intolerance to gluten,
Treatments (other than those used for Crohn's disease) able to interfere with food intake,
Aversion to foods consumed or smelled,
Poor understanding of cognitive tasks required.
Crohn's disease complicated by an abscess or infectious complication