Progesterone Induced Blocking Factor Expression Levels in Endometrial Cancer Cells.
|ClinicalTrials.gov Identifier: NCT02852954|
Recruitment Status : Completed
First Posted : August 2, 2016
Last Update Posted : August 18, 2017
Kayseri Education and Research Hospital
Information provided by (Responsible Party):
Erdem Sahin, Kayseri Education and Research Hospital
Immune system suppression effect of Progesterone Induced Blocking Factor(PIBF), it could be questionable whether tumor cells express PIBF for escape of immune system. There are some studies in the literature that evaluate PIBF expression of different malign cells (e.g. glioblastoma multiforme as a malign central nerve system, leukemia, astrocytoma as a primary brain tumor, lung cancer and chorionic carcinoma). According to previous studies PIBF has been used as an anti-tumor immune suppressor by tumor cells. There is no data about the PIBF expression of endometrial tumor cells. Therefore, the investigators aim to determine the PIBF expression levels in the endometrial cancer cells.
|Condition or disease|
|Progesterone Induced Blocking Factor in Endometrial Cancer|
This retrospective controlled study will be conducted at both Obstetrics and Gynecology clinics and Pathology clinics of Kayseri Training and Research Hospital. This study will be conducted with the use of formalin fixed paraffin embedded tissue blocks immunohistochemically to determine the PIBF expression levels in the samples. There are three groups in this study; endometrial cancer, endometrial hyperplasia and normal endometrium and each of the groups contained 20 paraffin embedded blocks provided form the Pathology clinic of Kayseri Training and Research Hospital archives.
|Study Type :||Observational|
|Actual Enrollment :||60 participants|
|Official Title:||Determining Levels of Expression of Progesterone-Induced Blocking Factor in Endometrial Cancer Cells.|
|Actual Study Start Date :||August 2016|
|Actual Primary Completion Date :||December 2016|
|Actual Study Completion Date :||March 2017|
20 paraffin embedded blocks which was diagnosed endometrial cancer
20 paraffin embedded blocks of healthy women
20 paraffin embedded blocks which was diagnosed endometrial hyperplasia
Primary Outcome Measures :
- Immunohistochemically Levels of PIBF in Endometrial Cancer Cells [ Time Frame: 3 months ]
No Contacts or Locations Provided