Factors Related to Geographical Variation in the Incidence of End-stage Renal Failure: An Analysis in 5 French Regions (VIgIE)
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|ClinicalTrials.gov Identifier: NCT02849964|
Recruitment Status : Completed
First Posted : July 29, 2016
Last Update Posted : July 29, 2016
The REIN registry highlights significant disparities in the incidence of end-stage renal disease (ESRD) between regions, especially in the North East of France. According to the literature, the incidence of ESRD in an area could be related to contextual factors influencing the needs for dialysis or transplantation (age structure, prevalence of risk factors, socioeconomic and morbidity levels), as well as to primary and secondary care provision (general practitioners and nephrologists) and to practice patterns in nephrology.
The aims of this project are the following:
- to compare the incidence of renal replacement therapy (dialysis or preemptive transplantation) for ESRD between the "départements" and the "cantons" belonging to the 5 regions of Eastern France (Alsace, Lorraine, Champagne-Ardenne, Bourgogne and Franche-Comté), while taking into account differences in population sizes and spatial patterns of the data,
- to analyse the relations between incidence disparities and socioeconomic environment, geographic accessibility to primary and secondary care and medical practice patterns, after adjusting for morbidity and mortality rates (incidence of diabetes, cardiovascular mortality).
This project will enable a better understanding of the mechanisms involved in the spatial variations of ESRD incidence, while disentangling effects related to the need from effects related to service supply in different socio-economic contexts. It will be possible to identify a lack of equity in access to renal replacement therapy if, after adjusting for need indicators, there were variations of incidence of ESRD related to availability of service or to socioeconomic context. Highlighting such effects would lead to search for corrective measures in collaboration with the different stakeholders.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||6835 participants|
|Observational Model:||Ecologic or Community|
|Official Title:||Factors Related to Geographical Variation in the Incidence of End-stage Renal Failure: An Analysis in 5 French Regions|
|Study Start Date :||September 2015|
|Actual Primary Completion Date :||June 2016|
|Actual Study Completion Date :||June 2016|
First time renal replacement therapy
Patients beginning renal replacement therapy by renal dialysis or preemptive kidney transplant.
- Factors associated with renal replacement therapy [ Time Frame: Study period: 2010-2014 ]Analysis of the association between renal replacement therapy incidence disparities and socioeconomic environment, geographic accessibility to primary and secondary care and medical practice patterns.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02849964
|Centre d'Investigation Clinique, CHU de Besançon|
|Besançon, France, 25030|
|Hôpital William Morey, Néphrologie|
|Chalon sur Saône, France, 73121|
|CHU de Reims, Néphrologie|
|Reims, France, 51100|
|Centre d'Investigation Clinique CHU de Nancy|
|Vandoeuvre-les-Nancy, France, 54500|
|Principal Investigator:||Elisabeth Monnet, MD, PhD||Centre d'Investigation Clinique, CHU Besançon|
|Principal Investigator:||Carole Ayav, MD||Centre d'Investigation Clinique, CHU Nancy|