Evaluation of Adipokines and Fat Tissue in Psoriasis and Psoriatic Arthritis (ADIPSO)
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|ClinicalTrials.gov Identifier: NCT02849795|
Recruitment Status : Completed
First Posted : July 29, 2016
Last Update Posted : February 12, 2018
Body composition analysis and especially body fat distribution in regions of interest (android and in particular intra-abdominal region) provides some information on the risk of cardiovascular disease. There is little data available on the body composition analysis in psoriasis and psoriatic arthritis (diseases with higher risk of cardiovascular disease), in particular data on fat distribution in regions of interest regarding the risk of cardiovascular disease.
Adipokines, secreted by the adipose tissue, have pro or anti-inflammatory and metabolic properties that are interesting to explore in pathologies with a higher risk of cardiovascular disease like psoriasis or psoriatic arthritis.
Adipokines have been investigated in psoriasis but fat tissue and in particular its distribution (android/visceral or intra-abdominal) has not been studied in parallel. Moreover, relation between adipokines and psoriasis area or severity has been studied but the relation between adipokines and cardiovascular risk factors has not yet been investigated.
The aim of this study is to investigate relations between the body fat distribution, adipokines rates and the risk of cardiovascular disease of these patients.
|Condition or disease||Intervention/treatment||Phase|
|Psoriasis Arthritic Psoriasis||Other: bone densitometry Other: questionnaires Other: biological analyses||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||199 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Evaluation of Adipokines and Fat Tissue in Psoriasis and Psoriatic Arthritis and Assessment of Their Relations With the Risk of Cardiovascular Disease|
|Study Start Date :||April 2014|
|Actual Primary Completion Date :||October 17, 2017|
|Actual Study Completion Date :||October 17, 2017|
Experimental: Psoriasis and arthritic psoriasis
additional blood sample for biological analyses bone densitometry questionnaires
Other: bone densitometry
Other: biological analyses
- Android fat distribution measured by bone densitometry (DEXA) (LUNAR GE iDXA device) [ Time Frame: day 1 ]
- Body fat [ Time Frame: day 1 ]
- body masses [ Time Frame: day 1 ]
- Intra-abdominal body fat mass (measured by CoreScan) [ Time Frame: day 1 ]
- Gynoid distribution of body fat [ Time Frame: day 1 ]
- SCORE (Systematic COronary Risk Evaluation). [ Time Frame: day 1 ]
- levels of adipokines [ Time Frame: day 1 ]
- Homeostasis model assessment of insulin resistance [ Time Frame: day 1 ]
- Bone mineral density of rachis, femoral neck, whole body [ Time Frame: day 1 ]
- levels of ghrelin [ Time Frame: day 1 ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02849795
|Besancon, France, 25030|