Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease
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|ClinicalTrials.gov Identifier: NCT02848378|
Recruitment Status : Completed
First Posted : July 28, 2016
Last Update Posted : July 28, 2016
|Condition or disease|
|Inflammation Periodontal Disease|
Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.
Advanced oxidation protein product is identified as a new marker of protein oxidation.
Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.
|Study Type :||Observational|
|Actual Enrollment :||75 participants|
|Observational Model:||Case Control|
|Official Title:||The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health|
|Study Start Date :||May 2014|
|Actual Primary Completion Date :||January 2015|
|Actual Study Completion Date :||April 2015|
Chronic periodontitis group
Subjects who have moderate to severe alveolar bone loss and clinical attachment level (CAL) ≥5 mm and probing depth (PD) ≥6mm in multiple sites of all four quadrants of the mouth but with no evidence of rapid progression
Subjects who show gingival inflammation that is based on the presence of bleeding on probing (BOP) at >50% of sites in the whole mouth, no clinical and radiographic signs of periodontitis
Periodontally healthy group
Subjects who have no sites with PD >3mm and CAL >0 mm, a BOP score of <15% at the examination and no alveolar bone loss.
- Advanced oxidation protein product (nmol) [ Time Frame: Before periodontal treatment ]
- Monocyte chemoattractant protein-1(pg) [ Time Frame: Before periodontal treatment ]
- The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3) [ Time Frame: Before periodontal treatment ]