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Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease

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ClinicalTrials.gov Identifier: NCT02848378
Recruitment Status : Completed
First Posted : July 28, 2016
Last Update Posted : July 28, 2016
Sponsor:
Information provided by (Responsible Party):
Meltem Karsiyaka Hendek, Kırıkkale University

Brief Summary:
This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health. 25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included into this study. In each participant, four sites are identified for gingival crevicular fluid samples.

Condition or disease
Inflammation Periodontal Disease

Detailed Description:

Oxidative stress is the disequilibrium between the formation of free radicals and antioxidant defense mechanisms via damaging cellular macromolecules (DNA, protein, lipid, etc..) which are susceptible to oxidative damage.

Advanced oxidation protein product is identified as a new marker of protein oxidation.

Monocyte chemoattractant protein-1 is a major chemoattractant for lymphocytes, monocytes and macrophages.


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Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: The Levels of Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Gingival Crevicular Fluid in Periodontal Disease and Health
Study Start Date : May 2014
Actual Primary Completion Date : January 2015
Actual Study Completion Date : April 2015

Group/Cohort
Chronic periodontitis group
Subjects who have moderate to severe alveolar bone loss and clinical attachment level (CAL) ≥5 mm and probing depth (PD) ≥6mm in multiple sites of all four quadrants of the mouth but with no evidence of rapid progression
Gingivitis group
Subjects who show gingival inflammation that is based on the presence of bleeding on probing (BOP) at >50% of sites in the whole mouth, no clinical and radiographic signs of periodontitis
Periodontally healthy group
Subjects who have no sites with PD >3mm and CAL >0 mm, a BOP score of <15% at the examination and no alveolar bone loss.



Primary Outcome Measures :
  1. Advanced oxidation protein product (nmol) [ Time Frame: Before periodontal treatment ]

Secondary Outcome Measures :
  1. Monocyte chemoattractant protein-1(pg) [ Time Frame: Before periodontal treatment ]
  2. The probing depth (mm), clinical attachment level (mm), plaque index scores (0-3) and gingival index scores (0-3) [ Time Frame: Before periodontal treatment ]


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Ages Eligible for Study:   18 Years to 66 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
25 participants with chronic periodontitis, 25 participants with gingivitis and 25 periodontally healthy subjects are included.
Criteria

Inclusion Criteria:

  • Clinical diagnosis of chronic periodontitis and gingivitis

Exclusion Criteria:

  • Systemic illnesses
  • Any medications known to affect the periodontium
  • Pregnancy and lactation

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Responsible Party: Meltem Karsiyaka Hendek, Corresponding author, Clinical Research, Kırıkkale University
ClinicalTrials.gov Identifier: NCT02848378     History of Changes
Other Study ID Numbers: 2014/17
First Posted: July 28, 2016    Key Record Dates
Last Update Posted: July 28, 2016
Last Verified: July 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Meltem Karsiyaka Hendek, Kırıkkale University:
Advanced Oxidation Protein Products
Gingival crevicular fluid
Monocyte chemoattractant protein-1
Periodontal Disease
Additional relevant MeSH terms:
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Periodontal Diseases
Inflammation
Pathologic Processes
Mouth Diseases
Stomatognathic Diseases