Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Subjective Perception of Motor Control During Psychogenic Disorders (PERCMO-TNF)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02843932
Recruitment Status : Recruiting
First Posted : July 26, 2016
Last Update Posted : December 27, 2019
Sponsor:
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:

The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder.

The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin.

Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.


Condition or disease Intervention/treatment Phase
Somatoform Disorders Other: functional brain MRI Not Applicable

Detailed Description:
New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 32 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.
Actual Study Start Date : May 13, 2015
Estimated Primary Completion Date : April 2020
Estimated Study Completion Date : April 2020

Arm Intervention/treatment
Experimental: Psychogenic disorders
Psychogenic movement disorders and seizures
Other: functional brain MRI
functional imagery during motor-perception tasks




Primary Outcome Measures :
  1. Familiarization with the joystick. [ Time Frame: 30 minutes ]
    HHSC-JOY-I from Current Designs. They are asked to trace a straight line.

  2. Brain MRI [ Time Frame: One hour and a half ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Signed informed consent
  • Medical exam médical done before study participation
  • Between 18 and 65 years
  • Right-handed persons
  • Conversion disorder based on DSM IV-R criterias
  • Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion Criteria:

  • Subjects included in a clinical and/or therapeutic exeprimentation in progress
  • People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
  • Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
  • History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
  • Alcohol ingestion
  • Pregnant, parturient or breastfeeding women
  • All other categories of protected persons

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02843932


Contacts
Layout table for location contacts
Contact: LAURENT VERCUEIL, MD PhD 33670316120 lvercueil@chu-grenoble.fr

Locations
Layout table for location information
France
Chu Grenoble Recruiting
Grenoble, France, 38043
Contact: LAURENT VERCUEIL, MD PhD    33670316120    lvercueil@chu-grenoble.fr   
Sponsors and Collaborators
University Hospital, Grenoble
Investigators
Layout table for investigator information
Study Chair: Tiphaine Montagnon DRCI, CHU GRENOBLE, FRANCE
Publications:
Cojan Y, Vuilleumier P. Functional brain imaging of psychogenic paralysis during conversion and hypnosis
Hallet M, cloninger CR, Fahn S, Halligan P, Jankovic J, Lang AE, Voon V Psychogenic movement disorders and other conversion disorders. Cambridge University Press 2011

Layout table for additonal information
Responsible Party: University Hospital, Grenoble
ClinicalTrials.gov Identifier: NCT02843932    
Other Study ID Numbers: 38RC14.120*
First Posted: July 26, 2016    Key Record Dates
Last Update Posted: December 27, 2019
Last Verified: December 2019
Keywords provided by University Hospital, Grenoble:
Somatoform
Psychogenic
Additional relevant MeSH terms:
Layout table for MeSH terms
Somatoform Disorders
Mental Disorders