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Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients

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ClinicalTrials.gov Identifier: NCT02843477
Recruitment Status : Completed
First Posted : July 25, 2016
Last Update Posted : July 17, 2018
Sponsor:
Information provided by (Responsible Party):
Yonsei University

Brief Summary:
It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume change. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography can be a predictor of fluid responsiveness in spontaneously breathing patients before induction of general anesthesia.

Condition or disease Intervention/treatment
Brain Tumor Device: ultrasonographic measurement of corrected flow time in carotid artery

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Study Type : Observational
Actual Enrollment : 54 participants
Observational Model: Other
Time Perspective: Prospective
Actual Study Start Date : August 9, 2016
Actual Primary Completion Date : February 28, 2017
Actual Study Completion Date : February 28, 2017

Group/Cohort Intervention/treatment
Fluid loading group
Spontaneously breathing patients before induction of general anesthesia who receive fluid loading
Device: ultrasonographic measurement of corrected flow time in carotid artery
Corrected carotid artery flow time is measured using 10-5 MHz linear probe on a portable ultrasound machine. On the two-dimensional image, the optimal image of the long-axis view is obtained at the left common carotid artery. The sample volume is placed on the center of the lumen, 2 cm proximal to the bulb, and a pulsed wave Doppler examination was performed while the Doppler beams were adjusted to ensure < 60° of angle for the best signal. Then, cardiac cycle time and carotid flow time is measured. Carotid flow time is measured between the upstroke of the flow tracing and the dicrotic notch, and it is corrected for pulse rate by dividing flow time by the square root of the cardiac cycle time to calculate corrected carotid artery flow time (flow time/√cycle time).




Primary Outcome Measures :
  1. ultrasonographic measurement of corrected flow time in carotid artery [ Time Frame: right before fluid loading ]
    The ultrasonographic measurement of corrected flow time in carotid artery will be performed before fluid loading.

  2. ultrasonographic measurement of corrected flow time in carotid artery [ Time Frame: 5 minutes after fluid loading ]
    The ultrasonographic measurement of corrected flow time in carotid artery will be performed 5 minutes after fluid loading.



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Ages Eligible for Study:   19 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who were scheduled to undergo elective neurosurgery for brain tumor
Criteria

Inclusion Criteria:

  • adult patients (19-80 years of age) who were scheduled to undergo elective neurosurgery for brain tumor

Exclusion Criteria:

  • BMI > 35 or < 15 kg/m2
  • the presence of carotid artery stenosis > 50%
  • systolic blood pressure > 160 mmHg
  • cardiac rhythm other than sinus
  • intracardiac shunt 6. valvular heart disease
  • a left ventricular ejection fraction of < 50%
  • right ventricular dysfunction 9
  • chronic obstructive pulmonary disease
  • pulmonary hypertension
  • chronic kidney disease (eGFR < 60 mL/min/1.73m2)
  • pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02843477


Locations
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Korea, Republic of
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine
Seoul, Korea, Republic of, 03722
Sponsors and Collaborators
Yonsei University
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT02843477    
Other Study ID Numbers: 4-2016-0426
First Posted: July 25, 2016    Key Record Dates
Last Update Posted: July 17, 2018
Last Verified: July 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Additional relevant MeSH terms:
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Brain Neoplasms
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Neoplasms
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases