Association Study Postoperative Cognitive Dysfunction Associated With Inflammation Polymorphism
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT02843152|
Recruitment Status : Unknown
Verified July 2016 by dengji wang, Xuzhou Medical University.
Recruitment status was: Recruiting
First Posted : July 25, 2016
Last Update Posted : July 25, 2016
This study use Loewenstein cognitive function rating scale to meet the standards of the elderly cognitive function assessment. POCD diagnostic criteria used is the recommended value Z current international law, in order to reduce the effects of exercise, we selected 50 cases of patients with age-matched healthy control group as a spouse, the same scale testing. And Loewenstein Assessment Scale cognitive function after some domestic research proved to have good sensitivity, and easy to test small changes in cognitive ability.
Before the investigation began strict inclusion and exclusion criteria, the use of simple intelligence scale exclude preoperative cognitive decline in the elderly significantly, the use of depression rating scale for anxiety rating scale before surgery to exclude severe depression and severe anxiety in elderly self self patient. Testing by the same person in the same way neurocognitive assessment test twice, 7 days apart.
Studies in Chinese population, susceptibility SNPs and genetic POCD but there are few reports of this project uses 1: 1 matched case-control study, by comparison POCD SNPs and control groups of different polymorphisms, polymorphisms Discussion Han population of postoperative cognitive dysfunction associated with susceptibility to find Chinese Han population of postoperative cognitive disorders genetic susceptibility markers, which provide scientific screening and early diagnosis of postoperative cognitive impairment at high risk in accordance with
|Condition or disease|
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||330 participants|
|Target Follow-Up Duration:||1 Week|
|Official Title:||Risk Factor Analysis of Postoperative Cognitive Dysfunction and Its Association With Inflammation Related Gene Polymorphism|
|Study Start Date :||May 2015|
|Estimated Primary Completion Date :||September 2016|
|Estimated Study Completion Date :||September 2016|
- Determine the relevance of inflammation-related genes and SNPs of susceptible POCD [ Time Frame: 1 year ]In this study of an international research organization POCD recommended Z-score method to determine postoperative cognitive dysfunction, and is divided into POCD and non POCD group, if the composite Z-score ≥1.96 or have two or more individual test Z-score greater than or equal 1.96 considers the patient POCD group, otherwise non POCD group. They were recorded POCD group and non-POCD group education of patients, medical history, surgery time, anesthesia time, and the amount of narcotic drugs, hypotension, hypertension, postoperative pain, complications, smoking, drinking, blood samples were analyzed patient patients with IL-1β, IL-6, IL-10, VDR, BDNF gene polymorphism
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02843152
|Contact: dengji email@example.com|
|Contact: yaodong zhang||+8615205217216|
|Affiliated Hospital of Xuzhou Medical College||Recruiting|
|Xuzhou, Jiangsu, China, 221000|
|Contact: dengji wang +8618761420798 firstname.lastname@example.org|
|Contact: yaodong zhang +8615205217216|
|Study Chair:||junli cao||Jiangsu Key Laboratory of Anesthesiology chinese|