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Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02842593
Recruitment Status : Completed
First Posted : July 25, 2016
Last Update Posted : January 16, 2017
Sponsor:
Information provided by (Responsible Party):
Stuart Phillips, McMaster University

Brief Summary:
This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Condition or disease Intervention/treatment Phase
Weight-Lifting Exercise Program Behavioral: Lower-repetition, heavier-load Behavioral: Higher-repetition, lighter-load Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
Study Start Date : September 2014
Actual Primary Completion Date : August 2016
Actual Study Completion Date : August 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Resistance exercise training
Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.
Behavioral: Lower-repetition, heavier-load
8-12 reps/set at ~80% 1 repetition maximum

Behavioral: Higher-repetition, lighter-load
20-25 reps/set at ~30% 1 repetition maximum

No Intervention: Non-exercising control
Continue habitual physical activity for 12 weeks.



Primary Outcome Measures :
  1. Carotid-femoral pulse wave velocity [ Time Frame: 12 weeks post exercise training ]
    Assessed using applanation tonometry


Secondary Outcome Measures :
  1. Common carotid artery distensibility [ Time Frame: 12 weeks post exercise training ]
    Assessed using vascular ultrasound

  2. Left ventricular mass [ Time Frame: 12 weeks post exercise training ]
    Assessed using standard echocardiography



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male
  • Aged 18-30 years old
  • Non-obese (Body mass index less than 30 kg/m2)
  • Non-smoker
  • Healthy based on questionnaire responses
  • Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion Criteria:

  • Allergies to milk proteins (whey or casein)
  • Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
  • Arthritic conditions
  • Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
  • A history of neuromuscular problems
  • Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02842593


Locations
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Canada, Ontario
McMaster University
Hamilton, Ontario, Canada, L8S4L8
Sponsors and Collaborators
McMaster University
Investigators
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Principal Investigator: Stuart M Phillips, PhD McMaster University
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Responsible Party: Stuart Phillips, Professor, McMaster University
ClinicalTrials.gov Identifier: NCT02842593    
Other Study ID Numbers: REB 14-333-1
First Posted: July 25, 2016    Key Record Dates
Last Update Posted: January 16, 2017
Last Verified: January 2017