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Trial record 85 of 667 for:    CARBON DIOXIDE AND arterial

Brain Blood Flow: Age and Gender

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ClinicalTrials.gov Identifier: NCT02840851
Recruitment Status : Active, not recruiting
First Posted : July 21, 2016
Last Update Posted : August 13, 2019
Sponsor:
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
Baseline cerebral blood flow through the middle cerebral artery (MCA) and cerebral vasodilator response of the MCA to inhaled carbon dioxide (CO2) will be measured in young women, young men, older women, and older men using Magnetic Resonance (MR) imaging and transcranial Doppler ultrasound (TCD). Data collection techniques will be compared.

Condition or disease Intervention/treatment
Healthy Aging Device: MRI Device: TCD

Detailed Description:

The investigators have recently shown that cerebral blood flow responses to chemical stimuli are reduced in healthy older adults. The investigators also have preliminary data suggesting that sex differences in cerebrovascular regulation exist. The overall goal of this application is to extend on the investigators previous studies by employing advanced neuroimaging techniques to enhance the investigators understanding of neurovascular coupling in healthy aging. This study will collect clinically significant data with implications for the future risk of cognitive decline and Alzheimer's disease.

The research aims are:

  1. To determine the effect of age and sex on baseline cerebral blood flow through the middle cerebral artery (MCA).
  2. To determine the effect of age and sex on cerebral vasodilator responses.
  3. To determine if the cerebrovascular responses measured by transcranial Doppler ultrasound (TCD) are associated with the cerebrovascular responses measured by Magnetic Resonance (MR) imaging.

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Study Type : Observational
Estimated Enrollment : 48 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Brain Blood Flow Response to Hypercapnia in Healthy Adults: The Effect of Age and Sex
Study Start Date : August 2016
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Group/Cohort Intervention/treatment
Healthy young women
Healthy young women between the age of 20-34 years.
Device: MRI
Participants will undergo a MRI scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory rate and PetCO2 will be measured.
Other Name: Magnetic Resonance Imaging

Device: TCD
Participants will undergo a TCD scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory and PetCO2 will be measured.
Other Name: Transcranial Doppler Ultrasound

Healthy young men
Healthy young men between the age of 20-34 years.
Device: MRI
Participants will undergo a MRI scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory rate and PetCO2 will be measured.
Other Name: Magnetic Resonance Imaging

Device: TCD
Participants will undergo a TCD scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory and PetCO2 will be measured.
Other Name: Transcranial Doppler Ultrasound

Healthy older women
Healthy older women between the age of 50-64 years.
Device: MRI
Participants will undergo a MRI scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory rate and PetCO2 will be measured.
Other Name: Magnetic Resonance Imaging

Device: TCD
Participants will undergo a TCD scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory and PetCO2 will be measured.
Other Name: Transcranial Doppler Ultrasound

Healthy older men
Healthy older men between the age of 50-64 years.
Device: MRI
Participants will undergo a MRI scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory rate and PetCO2 will be measured.
Other Name: Magnetic Resonance Imaging

Device: TCD
Participants will undergo a TCD scan while two stepwise CO2 elevations are applied to the participant by adding fractional concentration of inspired CO2 (FICO2) at 4% and 6% each time. The end tidal CO2 (PetCO2) will be elevated and maintained constant for a few minutes at each target level. Breath-by-breath changes in respiratory and PetCO2 will be measured.
Other Name: Transcranial Doppler Ultrasound




Primary Outcome Measures :
  1. Middle Cerebral Artery Blood Flow Measurement [ Time Frame: 75 minutes ]
    Utilize the TCD and MR imaging to measure middle cerebral artery blood flow in the brain while the participant is at rest.

  2. Middle Cerebral Artery Blood Flow Reactivity to Hypercapnia [ Time Frame: 75 minutes ]
    Utilize the TCD and MR imaging to measure middle cerebral artery blood flow reactivity to hypercapnic gas.



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Ages Eligible for Study:   20 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects for this study will include healthy young adults (20-34 years old) and healthy older adults (50-69 years old). Both men and women will be eligible to participate in this study.
Criteria

Inclusion Criteria:

  • Between 20-34 or 50-69 years
  • Body mass index <34 kg/m2

Exclusion Criteria:

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
  • Older females only: subject is not post-menopausal

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02840851


Locations
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United States, Wisconsin
University of Wisconsin-Madison
Madison, Wisconsin, United States, 53706
Sponsors and Collaborators
University of Wisconsin, Madison
Investigators
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Principal Investigator: Jill N Barnes, PhD University of Wisconsin, Madison

Publications:
Barnes, JN, Taylor JL, Nicholson WT, and Joyner MJ. Sex differences in age-related changes in cerebral vasodilator responses. FASEB Journal. 2013.

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT02840851     History of Changes
Other Study ID Numbers: 2016-0403
First Posted: July 21, 2016    Key Record Dates
Last Update Posted: August 13, 2019
Last Verified: August 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by University of Wisconsin, Madison:
Magnetic Resonance Imaging
Transcranial Doppler Ultrasound
Hypercapnia
Additional relevant MeSH terms:
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Hypercapnia
Signs and Symptoms, Respiratory
Signs and Symptoms