Effect of rTMS of the Dorsolateral Prefrontal Cortex on Language Production in Healthy Participants
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|ClinicalTrials.gov Identifier: NCT02840396|
Recruitment Status : Completed
First Posted : July 21, 2016
Last Update Posted : October 9, 2019
|Condition or disease||Intervention/treatment||Phase|
|Language||Device: rTMS Device: Sham rTMS||Not Applicable|
Several studies investigating healthy or clinical populations have shown that (r)TMS applied over the dorsolateral prefrontal cortex (DLPFC) has an effect on language-related processes such as verbal working memory (Osaka et al., 2007), sentence comprehension (Cotelli et al., 2011) and language switching (Holtzheimer et al., 2005, Nardone et al., 2011).
Clinical observations and neuroimaging studies seem to confirm the role of executive functions and frontal structures in language processing in monolingual and bilingual subjects (e.g. Fabbro et al., 2000, Abutalebi & Green 2007). However, only few studies investigated the effects of modulation of cognitive control-networks on lexical access.
Aim and procedure:
The study will investigate the role of the DLPFC and executive functioning in L1 and L2 language processing. The core question is whether rTMS over the DLPFC will influence lexical access and language production.
Each participant will take part in two sessions: 1. rTMS session 2. Sham rTMS session. After the application of rTMS/Sham rTMS, the participants will conduct two language tasks (translation, picture naming) and a non-verbal task, while the EEG is recorded.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||22 participants|
|Intervention Model:||Crossover Assignment|
|Official Title:||Role of Executive Function in Language: an Experimental and Clinical Approach With Application to Mother Language and Second Language|
|Study Start Date :||March 2016|
|Actual Primary Completion Date :||June 2017|
|Actual Study Completion Date :||July 2017|
repetitive TMS (rTMS) can lead to temporary increases or decreases (depending on the protocol used) in excitability of the targeted area. This change in excitability has been shown to last beyond the duration of the stimulation.
|Sham Comparator: Sham rTMS||
Device: Sham rTMS
Sham rTMS (or placebo rTMS) refers to a control condition in which no physiological effect on the targeted cortical region occurs.
- Language production [ Time Frame: within 30 mins after rTMS/sham rTMS ]Picture naming task and word translation task
- non-verbal executive functions task [ Time Frame: within 30 mins after rTMS/sham rTMS ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02840396
|Laboratory for Cognitive and Neurological Sciences|
|Fribourg, Switzerland, 1700|
|Principal Investigator:||Jean-Marie Annoni, Prof. Dr.||University of Fribourg|