Effect of Iron Status on Occurrence of Non-transferrin-bound Iron (NTBI) in Serum in Response to an Oral Iron Load
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|ClinicalTrials.gov Identifier: NCT02831712|
Recruitment Status : Unknown
Verified July 2016 by Thomas Walczyk, National University, Singapore.
Recruitment status was: Active, not recruiting
First Posted : July 13, 2016
Last Update Posted : July 19, 2016
|Condition or disease||Intervention/treatment||Phase|
|Effect of Iron Status on Occurrence of NTBI||Dietary Supplement: Ferrous Fumarate||Not Applicable|
For Visit 1, blood samples will be collected to assess iron status. For Visit 2, after an overnight fast, iron supplement will be provided to participant before breakfast. Blood samples will be collected right before and 2 h after iron supplement consumption for NTBI analysis.
NTBI concentration before and after iron supplement consumption will be compared. Dependence of NTBI formation on markers of iron status (serum iron, transferrin, transferrin saturation, serum ferritin and hemoglobin) will be evaluated.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||50 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Iron Status on Occurrence of Non-transferrin-bound Iron (NTBI) in Serum in Response to an Oral Iron Load|
|Study Start Date :||April 2013|
|Estimated Primary Completion Date :||December 2016|
|Estimated Study Completion Date :||December 2016|
Ferrous Fumarate tablet 200 mg
Dietary Supplement: Ferrous Fumarate
One tablet of a commercial iron supplement (Ferrous Fumarate 200 mg, from Drug House of Australia) will be provided to participants after overnight fast. The intervention is only one time.
- Concentration of NTBI after an oral iron load [ Time Frame: 2 hour post dose ]Blood samples collected 2 h after the iron supplement consumption will be measured for NTBI concentration
- Dependence of NTBI concentration on markers of iron status (concentrations of serum iron, serum ferritin, transferrin saturation) [ Time Frame: 2 hour post dose ]Correlation between NTBI concentration and iron status indicators will be evaluated
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02831712
|National University of Singapore; National University Hospital|
|Principal Investigator:||Thomas Walczyk, Ph.D||National University, Singapore|