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Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods. (Lungbaro)

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ClinicalTrials.gov Identifier: NCT02830516
Recruitment Status : Completed
First Posted : July 13, 2016
Last Update Posted : January 8, 2018
Sponsor:
Information provided by (Responsible Party):
Stefan Lundin, Sahlgrenska University Hospital, Sweden

Brief Summary:
Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

Condition or disease Intervention/treatment
Anesthesia Other: Measurement of lung elastance by two methods

Detailed Description:

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method in which a PEEP-step is performed with a size which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in anesthetized patients prior to major surgery.

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Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods
Actual Study Start Date : June 2016
Actual Primary Completion Date : December 31, 2016
Actual Study Completion Date : December 31, 2016

Group/Cohort Intervention/treatment
Lung elastance - transpulmonary pressure
Lung elastance and transpulmonary pressure measured by tidal esophageal pressure variations and by performing a PEEP step
Other: Measurement of lung elastance by two methods
Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume




Primary Outcome Measures :
  1. Measurement of lung elastance [ Time Frame: At 1 hour ]
    Comparison of two method for measurements of lung elastance (Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume)



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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients which are anesthetized and muscle relaxed and are planned to undergo major surgery
Criteria

Inclusion Criteria:

  • Patient undergoing major surgery during anesthesia and muscle relaxation

Exclusion Criteria:

  • Patient with chronic obstructive lung disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02830516


Locations
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Sweden
Sahlgrenska University Hospital
Gothenburg, Sweden, S-413 45
Sponsors and Collaborators
Stefan Lundin
Investigators
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Principal Investigator: Stefan Lundin, Professor Sahlgrenska University Hospital, Sweden

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Stefan Lundin, Professor, Sahlgrenska University Hospital, Sweden
ClinicalTrials.gov Identifier: NCT02830516    
Other Study ID Numbers: LUA-74201
First Posted: July 13, 2016    Key Record Dates
Last Update Posted: January 8, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided