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The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults

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ClinicalTrials.gov Identifier: NCT02825823
Recruitment Status : Completed
First Posted : July 7, 2016
Last Update Posted : October 13, 2017
Sponsor:
Information provided by (Responsible Party):
Jonathan Little, University of British Columbia

Brief Summary:
The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.

Condition or disease Intervention/treatment Phase
Exercise Ketones Dietary Supplements Dietary Supplement: Ketone Salt Dietary Supplement: Placebo Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 10 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effects of Exogenous Ketones on Exercise Performance in Young Healthy Adults
Study Start Date : July 2016
Actual Primary Completion Date : June 1, 2017
Actual Study Completion Date : June 1, 2017

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Ketone Salts
Acute dose of beta-hydroxybutyrate potassium/sodium salt (0.2g beta-hydroxybutyrate/kg, 0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)
Dietary Supplement: Ketone Salt
Placebo Comparator: Placebo
Acute dose of taste-matched placebo (0.01g Potassium/kg, 0.01g Sodium/kg with 1 g Steviol Glycoside and 30 ml of lemon juice per dose)
Dietary Supplement: Placebo



Primary Outcome Measures :
  1. Respiratory Exchange Ratio (RER) during cycling exercise [ Time Frame: 0-18 minutes ]
    The RER during 18 minutes of steady-state exercise


Secondary Outcome Measures :
  1. 10 km Cycling Time Trial Performance [ Time Frame: Following 18 minutes of steady-state exercise ]
    10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise



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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Males aged 18-40
  • Ability to understand and communicate in English to answer questionnaires and interact with the research assistant
  • Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

Exclusion Criteria:

  • Diagnosed with diabetes or any other medical conditions that could affect metabolism.
  • Diagnosed with heart disease or taking anti-hypertensive medications.
  • Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)
  • Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet
  • Current consumption of ketone supplements
  • Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02825823


Locations
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Canada, British Columbia
University of British Columbia, Okanagan.
Kelowna, British Columbia, Canada, V1V 1V7
Sponsors and Collaborators
University of British Columbia
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Responsible Party: Jonathan Little, Assistant Professor, University of British Columbia
ClinicalTrials.gov Identifier: NCT02825823    
Other Study ID Numbers: H1601260
First Posted: July 7, 2016    Key Record Dates
Last Update Posted: October 13, 2017
Last Verified: October 2017