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Mid-term Effect of a Novel Sit-to-stand Workplace (ACTIVE OFFICE) on Cognitive and Physiological Parameters

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ClinicalTrials.gov Identifier: NCT02825303
Recruitment Status : Completed
First Posted : July 7, 2016
Last Update Posted : July 15, 2016
Sponsor:
Collaborator:
University of Vienna
Information provided by (Responsible Party):
Bernhard Schwartz, University of Applied Sciences Upper Austria

Brief Summary:
Prolonged sitting is a risk factor for cardiovascular and musculoskeletal diseases, diabetes, several types of cancer and all-cause mortality. In combination with static and awkward postures, the prevalence of musculoskeletal diseases can increase further. Although the implementation of sit-to-stand or active workstations can help to reduce sitting time, improve physical activity at work and promote health benefits, it might also lead to changes in cognitive functions such as productivity The purpose of this study is to evaluate the mid-term effect of a novel two desk sit-to-stand workplace on sitting time as well as physiological and cognitive parameters for healthy people of working age in comparison to their traditional workplace.

Condition or disease Intervention/treatment Phase
Sedentary Lifestyle Worksite Other: Workplace consisting of two height-adjustable desks Not Applicable

Detailed Description:

Measurements were made both in the field and in a laboratory. Field measurements were made and processed continuously over the 23-week intervention period. Laboratory measurements were made on two different days, one day prior to intervention, and one day following intervention (due to cross-over design, each subject underwent 4 total days of laboratory measurements). Field measurements were collected automatically at the participants' workstation in their working office.

Laboratory tests were conducted in a controlled, simulated work-space located at the University of Applied Sciences Campus Linz. All laboratory measurements were made in a controlled laboratory at the campus site Linz of the University of Applied Sciences Upper Austria. Temperature, air flow, humidity, lighting conditions (artificial light only) and noise level were controlled and set to be consistent with the subjects' typical working environment.

During the laboratory measurements, subjects either stood or sat upright in an ergonomic office chair, according to the study protocol. Subjects were encouraged to work as fast and as accurately as they could. To ensure identical testing conditions between subjects and to not unduly influence physiological parameters such as salivary cortisol level or heart rate variability, subjects were required to minimize excessive movement (e.g. standing up during the sitting periods).

In the first (initial) phase, participants were familiarized with the study protocol. Sitting time and weekly physical activity were determined via the IPAQ-questionnaire. Examples of each cognitive test implemented in the cognitive phase were executed according to their guidelines. A 30 minute break in a sitting posture was used to ascertain baseline heart-rate and cortisol level. Baseline heart-rate was calculated after a 20 minute rest for a 5 minute interval and saliva samples were collected at the end (30min) of the break.

In the second (cognitive) phase subjects participated in a test battery containing five blocks. Each block consisted of a working speed test (text editing task), an attentional test (d2R-test of attention) and a reaction time test (Stroop-test). These tests lasted for 30 minutes to fulfill recommendations regarding postural changes. To simulate "common" working conditions (computer based and non-computer based tasks), digital (text editing task, Stroop-test) as well as pen & paper (d2R-test) versions of the implemented tests were used. All blocks were executed in alternating postures (sit - stand - sit - stand - sit) and at the end of each block - after a 5 minute break - salivary samples were collected. The order of posture was not changed within groups or time.

In the third (final) phase participants were asked to estimate their workload by means of the NASA-TLX questionnaire followed by a 30 minute resting phase in a sitting posture. During both 30 min resting phases (initial & final) participants watched documentaries and were encouraged not to talk.

Salivary samples were collected after each break during the study protocol and on the following morning, 20 minutes after waking up, to ascertain cortisol awakening response (CAR). Salivary samples were centrifuged and stored at -80 °C for subsequent testing using a chemiluminescent immunoassay.

Heart-rate and trunk movements were measured from the start of the study protocol until the CAR measurement.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 18 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Mid-term Effect of a Novel Sit-to-stand Workplace (ACTIVE OFFICE) on Cognitive and Physiological Parameters
Study Start Date : January 2014
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Arm Intervention/treatment
Experimental: Novel workplace - first half
Intervention: A novel two-desk sit-to-stand workstation for 23 weeks; provided within the first half of the study. Traditional workstation within the second half of the study.
Other: Workplace consisting of two height-adjustable desks
Desk arrangements: self-determined by the participants Desk equipment: depending on pre-intervention condition - 1 or 2 screens per desk Build-up: one day prior to the intervention period at the location of the workplace Adjustment: together with the study leader

Experimental: Novel workplace - second half
Intervention: A novel two-desk sit-to-stand workstation for 23 weeks; provided within the second half of the study. Traditional workstation within the frist half of the study.
Other: Workplace consisting of two height-adjustable desks
Desk arrangements: self-determined by the participants Desk equipment: depending on pre-intervention condition - 1 or 2 screens per desk Build-up: one day prior to the intervention period at the location of the workplace Adjustment: together with the study leader

No Intervention: Control group
Control group subjects did not encounter any changes in their regular office environments. Traditional workstation for both halves of the study.



Primary Outcome Measures :
  1. Daily sitting time [ Time Frame: baseline and 23 weeks ]
    Changes in sitting time after 23 weeks in the experimental group compared with its own control period and the control group. Measuring methods: International Physical Activity Questionaire (IPAQ); self developed tracking software at the participants' workplace


Secondary Outcome Measures :
  1. Cognitive performance (composite outcome) [ Time Frame: baseline and 23 weeks ]
    Changes in cognitive performance after 23 weeks in the experimental group compared with its own control period and the control group. Measuring methods: Digital color-word-conflict stroop test, d2R-test of attention, text editing task, NASA-TLX


Other Outcome Measures:
  1. Stress response [ Time Frame: baseline and 23 weeks ]
    Changes in stress response after 23 weeks in the experimental group compared with its own control period and the control group. Measuring methods: Heart rate variability (HRV), salivary cortisol ELISA



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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy Caucasian (no acute or chronic diseases)
  • Normal weight or slightly overweight (BMI: 18.5 - 27.5 kg/m²)
  • Regularly working in sedentary office environments
  • Regular computer users
  • Fluent German speakers
  • Consented to participate

Exclusion Criteria:

  • Heavily overweight & Obesity (BMI > 27.5 kg/m²)
  • Short office stay duration (< 8 h / day or < 20 h / week)
  • Experience in sit-to-stand workstations
  • Acute or chronic diseases
  • Inability to stand
  • Visual impairments that had not been corrected
  • Color blindness
  • People planning to change their physical activity level
  • Regular smokers (> 1 cigarette /day)
  • Not consented to participate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02825303


Locations
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Austria
University of Applied Sciences Upper Austria
Linz, Upper Austria, Austria, 4020
Sponsors and Collaborators
University of Applied Sciences Upper Austria
University of Vienna
Investigators
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Study Director: Bernhard Schwartz, MSc University of Applied Sciences Upper Austria
Publications:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Bernhard Schwartz, Research Associate, University of Applied Sciences Upper Austria
ClinicalTrials.gov Identifier: NCT02825303    
Other Study ID Numbers: AO-8735-1
834185 ( Other Grant/Funding Number: Austrian Research Promotion Agency (FFG) )
First Posted: July 7, 2016    Key Record Dates
Last Update Posted: July 15, 2016
Last Verified: July 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: Data resulting from this study will be analyzed and published in the PIs' PhD-thesis and journal articles.
Keywords provided by Bernhard Schwartz, University of Applied Sciences Upper Austria:
postural changes
Height adjustable desk
Prolonged sitting
Cognitive performance