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Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

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ClinicalTrials.gov Identifier: NCT02805231
Recruitment Status : Completed
First Posted : June 17, 2016
Last Update Posted : January 10, 2017
Sponsor:
Collaborator:
Tianjin Medical University Eye Hospital
Information provided by (Responsible Party):
Lv Yingjuan, Tianjin Medical University Eye Hospital

Brief Summary:
This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

Condition or disease Intervention/treatment
Primary Open- Angle Glaucoma Other: Vitamin D receptor polymorphic analysis

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Study Type : Observational
Actual Enrollment : 300 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Associations of Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma
Study Start Date : July 2013
Actual Primary Completion Date : December 2014
Actual Study Completion Date : March 2015


Group/Cohort Intervention/treatment
primary open-angle glaucoma patients
vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients.
Other: Vitamin D receptor polymorphic analysis
randomly age-matched people
vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people.
Other: Vitamin D receptor polymorphic analysis



Primary Outcome Measures :
  1. gene polymorphisms of vitamin D receptor [ Time Frame: 1 day visit ]

Biospecimen Retention:   Samples With DNA
ApaI and Tru9I Polymorphisms


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Ages Eligible for Study:   55 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
primary open-angle glaucoma patients and randomly age-matched people as controls in the Han population of Tianjin China
Criteria

Inclusion Criteria:

  • intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion Criteria:

  • the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02805231


Locations
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China, Tianjin
Tianjin Medical University Eye Hospital
Tianjin, Tianjin, China, 300384
Sponsors and Collaborators
Lv Yingjuan
Tianjin Medical University Eye Hospital
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Responsible Party: Lv Yingjuan, department of ophthamology, Tianjin Medical University Eye Hospital
ClinicalTrials.gov Identifier: NCT02805231    
Other Study ID Numbers: tjykdxykyy4
First Posted: June 17, 2016    Key Record Dates
Last Update Posted: January 10, 2017
Last Verified: January 2017
Additional relevant MeSH terms:
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Glaucoma
Glaucoma, Open-Angle
Ocular Hypertension
Eye Diseases
Vitamin D
Vitamins
Micronutrients
Nutrients
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents