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Molecular and Imaging Studies of Cardiovascular Health and Disease (Biobank)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02804269
Recruitment Status : Recruiting
First Posted : June 17, 2016
Last Update Posted : June 17, 2016
Sponsor:
Information provided by (Responsible Party):
National Heart Centre Singapore

Brief Summary:
Biobank is a program which collects biological samples, health information and imaging data from consented patients and stored them at the core facility. These information would be used to study the molecular, imaging and outcome studies of cardiovascular health and disease.

Condition or disease Intervention/treatment
Healthy Dilated Cardiomyopathy Hypertrophic Cardiomyopathy Ischemic Heart Disease Other: Cardiovascular Magnetic Resonance Other: Fatmass measurement

Detailed Description:
This program recruits patient from National Heart Centre Singapore and collects their biological sample, health information and imaging data.The donated biospecimens will be stored indefinitely and used for any future research on molecular, imaging and outcome studies of cardiovascular health and disease.The same biological samples and imaging data will be obtained from consented healthy volunteers for comparison.

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Study Type : Observational
Estimated Enrollment : 5000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Molecular and Imaging Studies of Cardiovascular Health and Disease
Study Start Date : July 2013
Estimated Primary Completion Date : July 2033
Estimated Study Completion Date : July 2033


Group/Cohort Intervention/treatment
Healthy Volunteer
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.

Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage

Dilated Cardiomyopathy
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.

Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage

Hypertrophic cardiomyopathy
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.

Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage

Ischemic heart disease with reduced EF
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.

Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage

Ischemic heart disease with normal EF
Subjects will undergo the following study procedure: Cardiovascular Magnetic Resonance Imaging and fatmass measurement
Other: Cardiovascular Magnetic Resonance
For the evaluation of heart function and structure of the cardiovascular system.

Other: Fatmass measurement
It utilizes a scale machine to measure the body fat and skeletal muscle percentage




Primary Outcome Measures :
  1. Numbers of genetic variation in genes known to cause inherited cardiac condition and circulating biomarkers which are linked with DNA changes using advanced sequencing and informatics approaches [ Time Frame: 10 years ]

Biospecimen Retention:   Samples With DNA
whole blood and serum.


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patient will be recruited from primary care clinic and outpatient clinics from the National Heart Centre Singapore. For healthy volunteer, they will be recruited through poster and advertisement.
Criteria

There is no inclusion/exclusion criteria except for the age limit as this is a repository program.

Inclusion Criteria:

•Subject aged ≥ 16 years and ≤ 90 years.

Exclusion Criteria:

•No


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02804269


Contacts
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Contact: Siew Ching Kong (65) 67042275 kong.siew.ching@nhcs.com.sg
Contact: Stuart Cook, MBBS, PhD

Locations
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Singapore
National Heart Centre Singapore Recruiting
Singapore, Singapore, 169609
Sponsors and Collaborators
National Heart Centre Singapore
Investigators
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Principal Investigator: Stuart Cook, MBBS,PhD National Heart Centre Singapore
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Responsible Party: National Heart Centre Singapore
ClinicalTrials.gov Identifier: NCT02804269    
Other Study ID Numbers: 2013/605/C
First Posted: June 17, 2016    Key Record Dates
Last Update Posted: June 17, 2016
Last Verified: July 2013
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by National Heart Centre Singapore:
Healthy Volunteer
Dilated cardiomyopathy
Hypertrophic cardiomyopathy
ischemic heart disease
Cardiovascular Magnetic Resonance Imaging
Additional relevant MeSH terms:
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Heart Diseases
Cardiomyopathies
Myocardial Ischemia
Coronary Artery Disease
Cardiomyopathy, Hypertrophic
Cardiomyopathy, Dilated
Hypertrophy
Cardiovascular Diseases
Pathological Conditions, Anatomical
Vascular Diseases
Coronary Disease
Arteriosclerosis
Arterial Occlusive Diseases
Aortic Stenosis, Subvalvular
Aortic Valve Stenosis
Heart Valve Diseases
Cardiomegaly