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Emotional Brain Processes in Recreational Cannabis Users

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02801214
Recruitment Status : Completed
First Posted : June 15, 2016
Last Update Posted : February 2, 2017
Sponsor:
Collaborators:
German Research Foundation
University Hospital, Bonn
Information provided by (Responsible Party):
Benjamin Becker, University of Electronic Science and Technology of China

Brief Summary:
This fMRI study investigates neural correlates of emotion regulation, emotion processing and craving in recreational cannabis users.

Condition or disease Intervention/treatment
Recreational Cannabis Use Other: fMRI

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Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Effects of Recreational Cannabis Use on Brain Activation Patterns Associated With Emotional Processes
Study Start Date : May 2015
Actual Primary Completion Date : December 2015
Actual Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Marijuana

Group/Cohort Intervention/treatment
Recreational Cannabis Use
ages 18-40
Other: fMRI
Healthy control subjects
socio-demographically matched
Other: fMRI



Primary Outcome Measures :
  1. fMRI neural correlates of emotional brain processes in recreational cannabis users after 72 hours of abstinence [ Time Frame: one time point = fMRI assessment after 72 hours of abstinence ]
    Activation patterns in brain regions known to be involved in emotional processing and to be altered by cannabis use (e.g. striatum, prefrontal cortex, insula, ACC)


Secondary Outcome Measures :
  1. Ratings of subjective experience (affect, craving) [ Time Frame: one time point = during fMRI assessment after 72 hours of abstinence ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Recreational male cannabis users
Criteria

Inclusion Criteria:

  • Recreational cannabis use
  • 72 hours of abstinence

Exclusion Criteria:

  • neurological disorders
  • psychiatric disorders according to DSM-4
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Responsible Party: Benjamin Becker, Prof. Dr. rer. nat. Benjamin Becker, University of Electronic Science and Technology of China
ClinicalTrials.gov Identifier: NCT02801214    
Other Study ID Numbers: ART_Can_02
First Posted: June 15, 2016    Key Record Dates
Last Update Posted: February 2, 2017
Last Verified: February 2017
Keywords provided by Benjamin Becker, University of Electronic Science and Technology of China:
cannabis
fMRI
emotion
Additional relevant MeSH terms:
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Marijuana Abuse
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders