Protein Requirements for Active Adolescent Females (IAAO-AF)
|ClinicalTrials.gov Identifier: NCT02800239|
Recruitment Status : Completed
First Posted : June 15, 2016
Last Update Posted : April 1, 2019
Protein requirements in active individuals have been suggested to be greater than the current recommended dietary allowance (RDA).
Nutritional requirements for dietary amino acids in adolescents have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.
Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than the RDA based on nitrogen balance data.
The purpose of this study is to measure the protein requirement in adolescent, females using the IAAO technique in the presence of a variable intensity exercise stimulus.
|Condition or disease||Intervention/treatment||Phase|
|Increased Metabolic Requirement Healthy||Dietary Supplement: Amino Acid Intake||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||7 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Evaluation of Protein Requirements in Active Adolescent Females|
|Actual Study Start Date :||February 2016|
|Actual Primary Completion Date :||October 2017|
|Actual Study Completion Date :||December 31, 2017|
Experimental: Active, adolescent females
Subjects will receive different levels of amino acid intakes, varying from 0.2-2.67 g/kg/d
Dietary Supplement: Amino Acid Intake
Amino acid intakes will be varied at 0.2-2.67 g/kg/d
- 13CO2 (Carbon Dioxide) Excretion (µmol/kg/h) [ Time Frame: 4 hours/ study day ]
- [13C]Phenylalanine Oxidation (µmol/kg/h) [ Time Frame: 4 hours/ study day ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02800239
|Goldring Centre for High Performance Sport|
|Toronto, Ontario, Canada, M5S2C9|
|Principal Investigator:||Daniel Moore, PhD||University of Toronto|