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Staphylococcus Aureus Nasal Carriage (SANAC)

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ClinicalTrials.gov Identifier: NCT02796690
Recruitment Status : Completed
First Posted : June 13, 2016
Last Update Posted : June 13, 2016
Sponsor:
Information provided by (Responsible Party):
Hospices Civils de Lyon

Brief Summary:

The repeated exposition to S. aureus is considered as a determining factor of acquisition of the nasal colonization. The healthcare professionals are regularly in touch with this pathogenic bacterium. Prevalence of the nasal carriage of S. aureus in this population was the object of several studies but little took into account the respect for the rules of good hygienic practice. The results of our previous study carried out during the international congress of staphylococci (ISSSI, Lyon in August 26-30th, 2012) showed an association between the work in a hospital environment and the increase of the risk of nasal carriage. On the contrary, the use of the hydro-alcoholic solutions had a protective effect against this carriage. However, sized of the health care population of our study was limited.

The goal of this study is to confirm our previous results on a larger cohort of healthcare professionals. The main objective is to estimate the prevalence of nasal carriage according to the professional category and by taking into account the degree of conformity with good hygiene practices including the use of hydro-alcoholic solutions.


Condition or disease Intervention/treatment
Nasal Carriage of Staphylococcus Aureus Other: nasal swabs will be collected

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Study Type : Observational
Actual Enrollment : 310 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Staphylococcus Aureus Nasal Carriage Among Technical Staff of a Teaching Hospital: An Unexpected Group at Risk of Colonization
Study Start Date : April 2014
Actual Primary Completion Date : April 2014
Actual Study Completion Date : April 2014

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Group/Cohort Intervention/treatment
Group Methicillin susceptible Staphylococcus aureus (MSSA) Other: nasal swabs will be collected
After formal consent, nasal swabs are collected for each participant. SA nasal carriage and its susceptibility to methicillin is determined using a rapid PCR technique (GenExpert, Cepheid). Each participant is asked to complete a short questionnaire regarding some demographic variables, smoking habits, long-term medication, sector of activity, and direct manipulation of the pathogen.

Group methicillin resistant Staphylococcus aureus (MRSA) Other: nasal swabs will be collected
After formal consent, nasal swabs are collected for each participant. SA nasal carriage and its susceptibility to methicillin is determined using a rapid PCR technique (GenExpert, Cepheid). Each participant is asked to complete a short questionnaire regarding some demographic variables, smoking habits, long-term medication, sector of activity, and direct manipulation of the pathogen.




Primary Outcome Measures :
  1. Rate of nasal carriage of Staphylococcus aureus (SA) among employees of a teaching hospital in Lyon-France according to professional exposure and compliance with good hygiene practices. [ Time Frame: after 2 days ]

Secondary Outcome Measures :
  1. Prevalence of nasal carriage of Staphylococcus aureus (SA) methicillin susceptible (MSSA) or methicillin resistant (MRSA) among employees of a teaching hospital in Lyon-France. [ Time Frame: after 2 days ]
  2. Presence or not of nasal carriage of Staphylococcus aureus (SA) among employees of a teaching hospital in Lyon-France at particular conditions as long medication intake and overweight. [ Time Frame: after 2 days ]


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Ages Eligible for Study:   18 Years to 100 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Employees of a teaching hospital in Lyon-France
Criteria

Inclusion Criteria:

- Employees with Consent.

Exclusion Criteria:

- Presence of contraindicating medical conditions preventing nasal swabing


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02796690


Locations
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France
National Reference Center for Staphylococci, 59 boulevard Pinel
Bron, France, 69677
Sponsors and Collaborators
Hospices Civils de Lyon
Investigators
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Principal Investigator: François Vandenesch, Pr National Reference Center for Staphylococci

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Responsible Party: Hospices Civils de Lyon
ClinicalTrials.gov Identifier: NCT02796690     History of Changes
Other Study ID Numbers: 69HCL16_0337
First Posted: June 13, 2016    Key Record Dates
Last Update Posted: June 13, 2016
Last Verified: June 2016

Keywords provided by Hospices Civils de Lyon:
nasal carriage
Staphylococcus aureus
good hygiene practices

Additional relevant MeSH terms:
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Methicillin
Anti-Bacterial Agents
Anti-Infective Agents