Lung Recruitment Improves Right Ventricle Performance
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|ClinicalTrials.gov Identifier: NCT02795208|
Recruitment Status : Completed
First Posted : June 10, 2016
Last Update Posted : June 14, 2016
|Condition or disease||Intervention/treatment||Phase|
|Atelectasis||Procedure: Lung recruitment maneuver||Not Applicable|
Atelectasis is developed in 90% of anesthetized patients after surgery.
Protective ventilation with low tidal volumes and positive-end expiratory pressure (PEEP) promotes atelectasis with the potential right ventricle dysfunction induced by the increment in afterload (activation of the pulmonary hypoxic vasocontriction reflex).
Lung recruitment can improve the right ventricle performance caused by atelectasis because the pulmonary hypoxic vasocontriction reflex desapear in a normal aerated lungs.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Lung Recruitment Improves Right Ventricle Performance After Cardio-Pulmonary Bypass|
|Study Start Date :||March 2015|
|Actual Primary Completion Date :||March 2016|
|Actual Study Completion Date :||April 2016|
No Intervention: Control group
Patients received standard protective ventilation along the protocol.
Experimental: Recruitment maneuver group
Patient received a lung recruitment maneuver after cardiopulmonary bypass. The recruitment maneuver consists in 10 breaths at 40/20 cmH2O of plateau pressure and PEEP, respectively. Then, the .ventilatory settings back to protective ventilation but adding 10 cmH2O of PEEP to keep the lungs open.
Procedure: Lung recruitment maneuver
The lung recruitment maneuver consists in a brief and controlled increment in airways pressure (20 cmH2O of PEEP + 20 cmH2O of driving pressure) for 10 breaths.
- Right ventricle assessment by transesophageal echocardiography [ Time Frame: intraoperative ]
- Atelectasis assessment by transesophageal echocardiography [ Time Frame: intraoperative ]
- PaO2 and respiratory compliance [ Time Frame: intraoperative ]
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02795208
|Principal Investigator:||Silvina Longo, MD||Hospital Privado de Córdoba|