Oxidative Stress on Muscle Dysfunction in Hemodialysis Patient (POPEYE)
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|ClinicalTrials.gov Identifier: NCT02794142|
Recruitment Status : Unknown
Verified June 2016 by University Hospital, Montpellier.
Recruitment status was: Recruiting
First Posted : June 8, 2016
Last Update Posted : June 8, 2016
In hemodialysis patient (HD) a reduction of the skeletal muscle mass and strength has previously been reported. This muscle impairment constitutes an independent prognosis factor in HD patients. Oxidative stress and inflammation have been linked to the muscle impairment. The mitochondria is a classical producer and target of reactive oxygen species (ROS), and may thus constitute a central actor of the skeletal muscle impairment in HD patients. Therefore, the aim of the present study is to investigate the role of the muscle mitochondrial density on the muscle impairment in HD patients, in comparing the muscle mitochondrial density and oxidative stress in HD patients vs. healthy matched controls.
In order to assess the effect of the oxidative stress and inflammation on the muscle impairment in HD patients, muscle function assessements will be performed after renal transplantation (which lowers the oxidative stress and inflammation levels) in the HD patient group.
No therapeutic intervention will be tested in the present study.
|Condition or disease||Intervention/treatment||Phase|
|Chronic Renal Failure Requiring Hemodialysis||Procedure: renal transplantation||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||22 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Impact of the Oxidative Stress on the Skeletal Muscle Dysfunction in Hemodialysis Patient|
|Study Start Date :||May 2015|
|Estimated Primary Completion Date :||May 2017|
|Estimated Study Completion Date :||May 2018|
|Experimental: HD patient||
Procedure: renal transplantation
- Muscle mitochondrial density assessed on a quadriceps biopsy by immunochemistry [ Time Frame: 2 years ]
- Maximum voluntary contraction of the quadriceps (in Newton.meter) [ Time Frame: 2 years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02794142
|Contact: Farès GOUZI, MD, PhD||+33 467 335 email@example.com|
|Montpellier University Hospital||Recruiting|
|Montpellier, France, 34295|
|Contact: Farès GOUZI, MD, PhD +33 467 335 908 firstname.lastname@example.org|