Prospective Tumor Response Evaluation (Liver)
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|ClinicalTrials.gov Identifier: NCT02787954|
Recruitment Status : Terminated (PI transferred to another institution and did not take this study with him.)
First Posted : June 1, 2016
Last Update Posted : October 18, 2018
|Condition or disease||Intervention/treatment|
|Hepatocellular Cancer Metastatic Liver Cancer||Procedure: TACE Procedure: Y-90 Procedure: MWA Procedure: IRE|
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||10 participants|
|Target Follow-Up Duration:||5 Years|
|Official Title:||Prospective Evaluation of Tumor Response to Cancer Treatment Therapies|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||April 2017|
|Actual Study Completion Date :||April 2017|
Transcatheter Chemoembolization or TACE
A technique called transcatheter chemoembolization (TACE) is used for some patients with liver cancer that cannot be treated surgically. The procedure is a way of delivering cancer treatment directly to a tumor through minimally-invasive means.
Procedure for giving chemotherapy directly to tumor cells.
Other Name: Transcatheter arterial chemoembolization
Yittrium 90 or Y-90
Radioembolization is a minimally invasive procedure that combines embolization and radiation therapy to treat liver cancer. Tiny glass or resin beads filled with the radioactive isotope yttrium Y-90 are placed inside the blood vessels that feed a tumor. This blocks the supply of blood to the cancer cells and delivers a high dose of radiation to the tumor while sparing normal tissue.
Using a combination of radiation and chemotherapy directly on the tumor cells to cause cell death.
Other Name: Yittrium 90
Microwave Ablation or MWA
Microwave ablation (MWA), destroys liver tumors using heat generated by microwave energy. A CT scan or ultrasonic guidance is used to pinpoint the exact location of the tumor. A thin antenna, which emits microwaves, is then inserted into the tumor. The probe produces intense heat that ablates (destroys) tumor tissue, often within 10 minutes.
Using heat to kill tumor cells.
Other Name: Microwave Ablation
Irreversible electroporation (IRE) is a nonthermal method of destroying the cell. A cell is subjected to a powerful electrical field using high-voltage direct current (up to 3 kV); this creates multiple holes in the cell membrane and irreversibly damages the cell's homeostasis mechanism, leading to instant cell death.
Using energy to disrupt tumor cell activity, thereby causing cellular death.
Other Name: Irreversible Electroporation
- Time to progression [ Time Frame: 1 month to 3 years ]Time from initial treatment to progression as defined by RECIST criteria.
- 1 year survival [ Time Frame: 1 year ]Number of patients alive 1 year after treatment
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02787954
|United States, Texas|
|University of Texas Health Science Center Houston|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Derek L West, MD||University of Texas Healtlh Science Center at Houston|