Human Electrical-Impedance-Tomography Reconstruction Models
|ClinicalTrials.gov Identifier: NCT02773680|
Recruitment Status : Unknown
Verified May 2016 by Ass.-Prof. Dr. Stefan Boehme, Medical University of Vienna.
Recruitment status was: Not yet recruiting
First Posted : May 16, 2016
Last Update Posted : May 16, 2016
|Condition or disease||Intervention/treatment||Phase|
|Respiratory Monitoring||Device: "electrical impedance tomography"||Phase 3|
A major drawback of EIT is its relatively poor spatial resolution and its limitation in measuring changes in bioimpedance as compared to a reference state (and not absolute quantities). Therefore, the technique cannot differentiate between extrapulmonary structures (muscles, thorax, heart, large vessels, spine, etc.) and non-aerated lung tissues - which is a major limitation for the clinical use of information derived from EIT-imaging. Moreover, current EIT-reconstruction algorithms are based on the consideration of a complete circular thoracic shape and do not take into account the body contours and lung borders.
The investigators are convinced that EIT-derived dynamic bedside lung imaging can be advanced by morphing computed tomography (CT) scans of the respective thoracic levels with concomitant EIT images - thus enhancing EIT-image information with CT-data. Integrating the anatomy of thoracic shape and lung borders provided by high-spatial resolution multi detector CT-scans (MDCT) with high-temporal resolution EIT has the potential to improve image quality considerably. This data can be used to compute mean EIT-reconstruction models that further offer the possibility to develop novel and clinically meaningful EIT parameters.
Therefore, the investigators hypothesize that by integration of CT-scan information of body and lung contours (and by computing different EIT reconstruction models) the current methodological limitations of EIT technology can be overcome.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||160 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Assessment of CT-derived Thoracic Electrical-Impedance-Tomography Finite Element Models|
|Study Start Date :||May 2016|
|Estimated Primary Completion Date :||November 2016|
|Estimated Study Completion Date :||June 2017|
Experimental: Study cohort 1
"electrical impedance tomography"
Device: "electrical impedance tomography"
One continous electrical impedance tomography (EIT) measurement per subject of approximately 5 minutes duration (2 min prior to MDCT scanning, during end-inspiratory MDCT acquisition and 2 min after MDCT scanning)
- Electrical Impedance Tomography Finite Element Model [ Time Frame: approximately 1 year through study completion ]Based on CT-derived thorax, lung and heart contours we propose to calculate human finite element models (FEM) for EIT analysis
- height [ Time Frame: at the time-point of inclusion ]
- weight [ Time Frame: at the time-point of inclusion ]
- gender [ Time Frame: at the time-point of inclusion ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02773680
|Contact: Stefan Boehme, MD||+43 40400 firstname.lastname@example.org|
|Principal Investigator:||Stefan Boehme, MD||Department of General Anesthesia, Intensive Care Medicine and Pain Management, Medical University of Vienna, Austria|