Evaluation of Myocardial Perfusion Reserve (EVARESERVE)
|ClinicalTrials.gov Identifier: NCT02773043|
Recruitment Status : Completed
First Posted : May 16, 2016
Last Update Posted : January 2, 2020
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Device: CZT SPECT camera||Not Applicable|
Coronary artery disease is a public health problem. The measurement of myocardial perfusion reserve is a prognostic factor supplemental.
Its measure should influence the treatment and the follow up of the patients. The measurement of CRF by by one pressure-temperature sensor-tipped guide wire is a validated technique to evaluate the myocardial perfusion reserve but it is an invasive technique.
In this study, the investigators will compare this method with a non-invasive method: completely automated analysis and quantification of myocardial blood flow from DICOM files corresponding to stress and rest images was developed with a new camera CZT SPECT.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||36 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Actual Study Start Date :||December 2015|
|Actual Primary Completion Date :||July 2019|
|Actual Study Completion Date :||July 2019|
|non invasive imaging technique||
Device: CZT SPECT camera
- Correlation between the measure of the coronary flow reserve with an invasive reference method (thermodilution) and a new non-invasive method in scintigraphy to measure the myocardial perfusion reserve [ Time Frame: an average of 1 year ]
Coronary flow reserve by thermodilution is the ratio between mean transit time of a room temperature 3-ml bolus of saline during rest and maximal hyperemia.
Coronary flow reserve by CZT camera is given by ratio between Mycoardial perfusion during rest and maximal hyperemia. Myocardial perfusion is given by new software.
- Evaluation of the myocardial perfusion reserve measuring the CRF by thermodilution. [ Time Frame: an average of 1 year ]Coronary flow reserve by thermodilution is the ratio between mean transit time of a room temperature 3-ml bolus of saline during rest and maximal hyperemia.
- Evaluation of the myocardial perfusion reserve in scintigraphy by the same operator over different time scales and by two different operators. [ Time Frame: an average of 1 year ]Coronary flow reserve by CZT camera is given by ratio between Mycoardial perfusion during rest and maximal hyperemia. Myocardial perfusion is given by new software.
- Study the correlations between the level of soluble VE-cadherin (sVE) and the other indicators of coronary endothelial involvement (CRF and RMP). [ Time Frame: Day of coronarography ]Blood test for soluble VE-cadherin (sVE), CRF, RMP
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02773043
|La Tronche, France, 38700|
|Principal Investigator:||Gilles BARONE-ROCHETTE, MD, PhD||University Hospital, Grenoble|