Circulating PRCP in STEMI Patients Undergoing Primary PCI
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ClinicalTrials.gov Identifier: NCT02772133 |
Recruitment Status :
Completed
First Posted : May 13, 2016
Last Update Posted : January 3, 2020
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Condition or disease | Intervention/treatment |
---|---|
Myocardial Infarction Percutaneous Coronary Intervention PRCP | Procedure: Primary PCI |
Study Type : | Observational |
Actual Enrollment : | 275 participants |
Observational Model: | Case-Control |
Time Perspective: | Cross-Sectional |
Study Start Date : | May 2016 |
Actual Primary Completion Date : | July 2016 |
Actual Study Completion Date : | July 2016 |
Group/Cohort | Intervention/treatment |
---|---|
STEMI patients |
Procedure: Primary PCI |
Healthy subjects | |
Unstable angina |
- Circulating PRCP level [ Time Frame: 1 month ]
- Circulating PRCP activity [ Time Frame: 1 month ]
- Circulating Ang II level [ Time Frame: 1 month ]
- Circulating Ang-(1-7) level [ Time Frame: 1 month ]
- Circulating BK-(1-9) level [ Time Frame: 1 month ]
- Circulating KBK-(1-9) level [ Time Frame: 1 month ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Admitted for primary PCI for STEMI involving the LAD within 12 hours of onset of symptoms. STEMI will be defined as typical ECG changes (ST segment elevation ≥2mm in 2 or more precordial leads) associated with acute chest pain or an elevation of cardiac enzymes;
- Age ≥18 years;
- Informed consent from subject or next of kin.
Exclusion Criteria:
- Nonischaemic Cardiomyopathy;
- Cardiac surgery planed in the 6 months;
- Mechanical complication of STEMI (ventricular septal rupture, free wall rupture, acute severe mitral regurgitation);
- Renal or hepatic failure;
- Malignancy, HIV, or central nervous system disorder;
- Cardiopulmonary resuscitation >15 min and compromised level of consciousness;
- Cardiogenic shock;
- Current participation in any research study involving investigational drugs or devices;
- No written consensus;
- Previous myocardial infarction.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02772133
China, Shandong | |
Qianfoshan Hospital, Shandong University | |
Jinan, Shandong, China, 250012 | |
Shandong University Qilu Hospital | |
Jinan, Shandong, China, 250012 | |
Jinan Central Hospital, Shandong University | |
Jinan, Shandong, China, 250013 | |
Shandong Provincial Hospital, Shandong University | |
Jinan, Shandong, China, 250021 |
Responsible Party: | Pan-Pan Hao, MD, PhD, Qilu Hospital of Shandong University |
ClinicalTrials.gov Identifier: | NCT02772133 |
Other Study ID Numbers: |
2015GSF118133 |
First Posted: | May 13, 2016 Key Record Dates |
Last Update Posted: | January 3, 2020 |
Last Verified: | December 2019 |
Myocardial Infarction Infarction Ischemia Pathologic Processes Necrosis |
Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases |