Oral Contraceptives as Infertility Treatments for Premature Ovarian Failure
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|ClinicalTrials.gov Identifier: NCT02757469|
Recruitment Status : Not yet recruiting
First Posted : May 2, 2016
Last Update Posted : May 2, 2016
|Condition or disease||Intervention/treatment||Phase|
|Primary Ovarian Insufficiency Menopause, Premature||Drug: Drospirenone and ethinyl estradiol combination (Yasmin)||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Drospirenone and Ethinyl Estradiol Combinations (Yasmin) as Infertility Treatments for Premature Ovarian Failure: a Perspective Follow-up Study.|
|Study Start Date :||May 2016|
|Estimated Primary Completion Date :||May 2020|
|Estimated Study Completion Date :||May 2021|
Pregnancies will occur while the women are taking oral contraceptives (Yasmin). The possible role of exogenous estrogens in sensitizing the granulosa cells to the effect of follicle-stimulating hormone and thereby inducing ovulation and conception in some women with premature ovarian failure is examined.
Drug: Drospirenone and ethinyl estradiol combination (Yasmin)
Female oral combined contraceptive containing 30 mcg (0.030 mg) Ethinyl Estradiol and 3 mg drospirenone (Androstenes)
- live birth [ Time Frame: 3 years ]The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).
- clinical pregnancy rate [ Time Frame: 3 years ]The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
- multiple pregnancy [ Time Frame: 3 years ]The condition of carrying two or more FETUSES.
- miscarriage [ Time Frame: 3 years ]Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02757469
|Contact: Yunhai Chuai, Drfirstname.lastname@example.org|
|Navy General Hospital|
|Beijing, Beijing, China, 100048|
|Contact: Yunhai Chuai, Dr +86-18810892004 email@example.com|
|Principal Investigator: Wei Shang, Dr|
|Principal Investigator: Lei Chen, Dr|
|Principal Investigator: Yunhai Chuai, Dr|
|Sub-Investigator: Mingming Shu, Dr|
|Sub-Investigator: Ming Zhou, Dr|
|Sub-Investigator: Mengnan Chen, Dr|
|Sub-Investigator: Huiming Han, Dr|
|Principal Investigator:||Wei Shang, Dr||Navy General Hospital, Beijing|