Drug Resistance Factors In Healthcare-associated Pneumonia (DEFINE)
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|ClinicalTrials.gov Identifier: NCT02736097|
Recruitment Status : Completed
First Posted : April 13, 2016
Last Update Posted : August 1, 2017
|Condition or disease|
|Pneumonia Critical Illness|
Pneumonia is one of the leading causes of death in the United States and is associated with significant costs to the healthcare system. Recent treatment guidelines describe a new subtype of pneumonia, healthcare-associated pneumonia (HCAP), to identify those patients who present to a hospital from the community and are thought to be at greater risk for developing pneumonia due to multidrug resistant organisms (MDRO).
The HCAP categorization scheme is intended to improve the prescription of initial appropriate empiric antibacterial agents and minimize the morbidity and mortality associated with inappropriate empiric selection.However, one of the chief criticisms of the guideline recommendations is that the criteria used to define HCAP is overly broad, which may result in greater use of broad-spectrum antibiotics.
The prevailing notion is that many patients in the community will be at the lowest risk for experiencing MDR pneumonia and can be treated with a less broad anti-infective regimen. Patients with increasing exposure to the healthcare system will receive initial anti-infective therapy that is more broad in an effort to target MDROs. The investigator group believes that it is not simply exposure to the healthcare system that predicts the incidence of MDR pneumonia (i.e., criteria for HCAP), but rather, the "intensity" of exposure to the healthcare system that is predictive of MDR pneumonia. The aim of this study is to identify risk factors for MDR HCAP pneumonia in critically ill patients. .
|Study Type :||Observational|
|Actual Enrollment :||679 participants|
|Official Title:||A Multicenter Study to Evaluate Predictive Factors for Multidrug Resistant Healthcare Associated Pneumonia in Critically Ill Patients|
|Actual Study Start Date :||November 2016|
|Actual Primary Completion Date :||January 2017|
|Actual Study Completion Date :||February 28, 2017|
- Incidence of multidrug resistant pneumonia pathogen [ Time Frame: 30 days ]
- Incidence of pneumonia subtypes [ Time Frame: 30 days ]
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02736097
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