Colorado Marijuana Users Health Cohort
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ClinicalTrials.gov Identifier: NCT02735954 |
Recruitment Status : Unknown
Verified October 2018 by National Jewish Health.
Recruitment status was: Active, not recruiting
First Posted : April 13, 2016
Last Update Posted : March 13, 2019
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Condition or disease | Intervention/treatment |
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COPD Insomnia Cannabis | Other: Marijuana |
In Colorado, marijuana is currently used for both recreational and medicinal purposes. The major active drug is tetrahydrocannabinol (THC). The most common route of use is through inhalation of the combustion products of the dried, buds/flowers from the female plant either rolled in paper (joint) or burned through a screen in a dry or water filled pipe (bong). Increasingly THC is consumed.
The side effects of the inhalation of burned leaves are controversial. The purpose of this proposal is to establish a prospective cohort of heavy marijuana users to evaluate positive and negative long term medical effects of marijuana use. As marijuana has also been reported for use to help treat insomnia, a sub-study will focus on how marijuana is used for sleep disorders and disturbances.
This study will enroll individuals that use marijuana to learn more about long-term health effects. The study involves one visit where participants will complete questionnaires, breathing tests, blood and urine collection. There is a sub-study where eligible participants will also complete an at-home sleep monitoring test. Participants will be contacted multiple times a year for long-term follow-up.
Study Type : | Observational |
Estimated Enrollment : | 2000 participants |
Observational Model: | Cohort |
Time Perspective: | Cross-Sectional |
Official Title: | Colorado Marijuana Users Health Cohort |
Study Start Date : | September 2014 |
Estimated Primary Completion Date : | May 2019 |
Estimated Study Completion Date : | December 2019 |
Group/Cohort | Intervention/treatment |
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Marijuana Users
Individuals who use marijuana
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Other: Marijuana
This is an observational study looking at the effects of marijuana on health, including lung health and sleep. |
Combined Marijuana and Tobacco Users
Individuals who use marijuana and also smoke cigarettes
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Other: Marijuana
This is an observational study looking at the effects of marijuana on health, including lung health and sleep. |
Non-Marijuana Users
Individuals who do not use marijuana
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- Long term medical effects of marijuana use [ Time Frame: measured at baseline visit ]
- Quality of sleep [ Time Frame: measured at baseline visit ]physiological parameter and questionnaires
Biospecimen Retention: Samples With DNA

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Ages Eligible for Study: | 21 Years to 80 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Colorado-only study
- Age 21-80 years and one of the categories below
- Marijuana use: use of any cannabis (smoked, vaped, edible, etc.) on average more than 3 days per week for at least 1 year
- Combined marijuana use and Tobacco use (current or former): ≥ 30 pack year cigarette smoking history
- Non-marijuana users
Sleep sub-study:
Enrollment in the main cohort building study and a qualifying score on the Insomnia Severity Index questionnaire
Exclusion Criteria:
- Respiratory disorder other than COPD or asthma
- Lung surgery with removal of a lobe or more or lung volume reduction surgery
- Lung cancer or other cancer under active treatment during past 12 months
- ≥ 30 pack year cigarette smoking history for combined marijuana and cigarette users
- Pregnancy
- Use of antibiotics and/or systemic steroids for any lung infection within the last month
- Inability to use albuterol
- Subject enrolled in COPDGene or SPIROMICS
Sleep sub-study:
- Inability to complete home sleep study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02735954
United States, Colorado | |
National Jewish Health | |
Denver, Colorado, United States, 80206 |
Responsible Party: | National Jewish Health |
ClinicalTrials.gov Identifier: | NCT02735954 |
Other Study ID Numbers: |
HS 2854 |
First Posted: | April 13, 2016 Key Record Dates |
Last Update Posted: | March 13, 2019 |
Last Verified: | October 2018 |
Marijuana Abuse Mental Disorders Substance-Related Disorders Chemically-Induced Disorders |