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The Brain Heart Interaction in Acute Stroke

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ClinicalTrials.gov Identifier: NCT02734082
Recruitment Status : Completed
First Posted : April 12, 2016
Last Update Posted : April 12, 2016
Sponsor:
Information provided by (Responsible Party):
University Hospital Inselspital, Berne

Brief Summary:
Many studies have shown that acute cerebral dysfunction can impair cardiac function and autonomic control of blood pressure, heart rate and vascular tone, however, the size of the stroke is rarely reported. Involvement of the insular cortex seems to predispose to cardiac damage and autonomic dysfunction. However, it is not clear whether cardiac dysfunction is merely a marker of large strokes or location of the stroke is critical.

Condition or disease
Myocardial Infarction Stroke

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Study Type : Observational
Actual Enrollment : 204 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: The Brain Heart Interaction in Acute Stroke
Study Start Date : October 2013
Actual Primary Completion Date : March 2015
Actual Study Completion Date : March 2015

Group/Cohort
Elevated Troponin and pathological EC
Patients with acute ischemic stroke with elevated Troponin
No elevated Troponin or pathological EC
Patients with acute ischemic stroke without elevated Troponin
Elevated Troponin, pathological ECG & coronary angiography
Patients with acute ischemic stroke with elevated Troponin T and pathological ECG and coronary angiography
No elevated Troponin, pathological ECG & coronary angiography
Patients with acute ischemic stroke without elevated Troponin T and pathological ECG and coronary angiography



Primary Outcome Measures :
  1. Association of ischemic lesion size and impaired heart regulation at baseline [ Time Frame: At baseline ]
    Association is to be determined via multivariate logistic regression. Baseline parameter at inclusion; functional outcome/mortality after 3 months.

  2. Association of ischemic lesion size and impaired heart regulation after 3 months [ Time Frame: After 3 months ]
    Association is to be determined via multivariate logistic regression. Baseline parameter at inclusion; functional outcome/mortality after 3 months.



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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients with acute ischemic stroke hospitalized at Inselpital Berne between 2004-2014.
Criteria

Inclusion Criteria:

  • Age ≥16 years
  • Hospitalized between 2004-2014
  • Acute MRI imaging performed
  • ECG on admission
  • Cardiac lab parameters on admission (TnT, CK, CK-MB)

Exclusion Criteria

  • Age <16 years
  • No acute MRI image
  • No lab parameters

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02734082


Locations
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Switzerland
Dep. of Neurology, Bern University Hospital, Bern
Berne, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Investigators
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Principal Investigator: Heinrich P Mattle, Prof. MD Dep. of Neurology, Bern University Hospital, Bern
Publications:
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Responsible Party: University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier: NCT02734082    
Other Study ID Numbers: 155/14
First Posted: April 12, 2016    Key Record Dates
Last Update Posted: April 12, 2016
Last Verified: April 2016
Keywords provided by University Hospital Inselspital, Berne:
stroke
ischemia
Berne
Additional relevant MeSH terms:
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Stroke
Myocardial Infarction
Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases