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The Impact of Epilepsy Surgery on Dream Content

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ClinicalTrials.gov Identifier: NCT02731443
Recruitment Status : Active, not recruiting
First Posted : April 7, 2016
Last Update Posted : August 13, 2018
Sponsor:
Information provided by (Responsible Party):
David Steven, London Health Sciences Centre

Brief Summary:
Prospective observational study on epilepsy patients undergoing partial brain resection surgery (i.e. anterior temporal lobectomy) to assess the change in dream content before and 3 months and 1 year after surgery using anonymized dream-recall questionnaires. A control group of epilepsy patients undergoing diagnostic depth electrodes placement will complete the same questionnaires pre- and postoperatively to asses the factor 'general anesthesia' as a potential confounder.

Condition or disease Intervention/treatment
Dream Content Procedure: Epilepsy surgery Procedure: Depth electrodes insertion

  Show Detailed Description

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Impact of Epilepsy Surgery on Dream Content
Actual Study Start Date : March 2016
Actual Primary Completion Date : July 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Epilepsy

Group/Cohort Intervention/treatment
ESx
Epilepsy patients undergoing elective surgical resection of brain tissue; study group: epilepsy surgery=ESx.
Procedure: Epilepsy surgery
Epilepsy surgery is a procedure that removes an area of the brain where seizures originate.

DE
Epilepsy patients undergoing elective depth electrodes insertion in general anesthesia; control group: depth electrodes=DE.
Procedure: Depth electrodes insertion
Depth electrodes are inserted for monitoring/mapping the subsurface levels of the brain for the surgical treatment of epilepsy.




Primary Outcome Measures :
  1. Percentage Change of Dream Features Occurrence (i.e. dream content; MOST RECENT DREAM questionnaire) - both groups (ESx & control group) [ Time Frame: 3 months ]

    Percentage change of the following dream features occurrences according to the Hall/Van de Castle system are considered:

    • Characters
    • Social Interactions
    • Aggression
    • Friendliness
    • Sexuality
    • Activities (walking, talking, seeing, thinking, etc.)
    • Success and Failure
    • Misfortune and Good Fortune
    • Emotions
    • Settings
    • Objects
    • Descriptive Elements (modifiers, time, negatives)

    The relative abundance of the dream content listed above will be expressed in percentage and postoperative changes compared to the preoperative baseline.

    Relative differences between the indicators will be determined and statistically tested for significance. The one indicator that turns out to be statistically different from the rest will be considered the primary outcome measure. For an example, compare Bentes et al. 2011.



Secondary Outcome Measures :
  1. Dream Content (MOST RECENT DREAM questionnaire) - ESx group [ Time Frame: 12 months ]
    Major indicators for main content categories according to the Hall/Van de Castle system.


Other Outcome Measures:
  1. Seizure frequency (ESx only) [ Time Frame: 3 and 12 months ]
    According to the ENGEL classification

  2. Anti epileptic drugs (AED) usage (ESx only) [ Time Frame: 3 and 12 months ]
    Number of different AED



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Ages Eligible for Study:   16 Years and older   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Epilepsy patients undergoing elective surgical resection of brain tissue (study group: Epilepsy surgery=ESx) or depth electrode insertion in general anesthesia (control group=DE).
Criteria

Inclusion Criteria:

  • All epilepsy patients (minimum age: 16 years) undergoing elective surgical resection of brain tissue (study group) or depth electrode insertion in general anesthesia (control group) that give written consent after thorough study information.
  • Patients must be able to understand the study concept and willing/able to document their most recent dream in written.

Exclusion Criteria:

  • Inability to document their most recent dream in written (language barrier, illiteracy, low intelligence, mental disabilities). Age <16 years.
  • Relevant co-morbidities such as dementia, depression and other psychiatric disorders, Parkinson's disease.
  • Previous cranial surgery in a relevant cortical area of the default dream network.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02731443


Locations
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Canada, Ontario
London Health Sciences Center, University Hospital
London, Ontario, Canada, N6A 5A5
Sponsors and Collaborators
London Health Sciences Centre
Investigators
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Principal Investigator: David A Steven, M.D. London Health Science Center

Publications of Results:
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Responsible Party: David Steven, David A. Steven, MD, MPH, FRCSC, FACS, London Health Sciences Centre
ClinicalTrials.gov Identifier: NCT02731443     History of Changes
Other Study ID Numbers: 107654
First Posted: April 7, 2016    Key Record Dates
Last Update Posted: August 13, 2018
Last Verified: August 2018
Keywords provided by David Steven, London Health Sciences Centre:
dreaming
epilepsy
neurosurgery
temporal lobectomy
Additional relevant MeSH terms:
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Epilepsy
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases