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Trial record 15 of 30 for:    Dermatophagoides pteronyssinus AND Dermatophagoides farinae

Impact of Age on the Prevalence of Allergic Sensitization

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ClinicalTrials.gov Identifier: NCT02730520
Recruitment Status : Completed
First Posted : April 6, 2016
Last Update Posted : September 12, 2016
Sponsor:
Information provided by (Responsible Party):
Olivier Michel, Brugmann University Hospital

Brief Summary:

Worldwide, respiratory diseases have a significant impact on morbidity and mortality of individuals.Tobacco, lifestyle and certain allergens such as dust mites play an important role in the prevalence and morbidity of these diseases. Scientific literature indicates that sensitization to allergens and respiratory diseases (asthma, rhinitis, chronic obstructive pulmonary disease) are closely linked. Moreover, smoking has an effect on allergen sensitivity.

To make a diagnosis of allergic sensitization, skin tests are performed in the patient. One of the methods used is the technique of "prick test". In practice, a drop of purified allergen extract is placed on the patient's skin (arms or back). A little dosis of the product is then injected in the epidermis. If fifteen minutes later, there is an edematous reaction, its diameter is measured in millimeters. From 4 mm, it is considered that the patient is sensitized to the tested foods or allergens.This technique is painless and convenient to patients of all ages, including newborns or conversely very aged patients.

This is a retrospective study based on the encoding and statistical analysis of data collected in patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital, who received an allergy assessment between 01/01/2015 and 31/12/2015. The allergens tested include: dermatophagoides pteronyssinus (DEPT), dermatophagoides farinae (DPF), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel.

At least 1400 files will be analyzed.

Patients will be distributed in six age groups.The results of the allergen skin tests will be encoded as the edema diameter. The allergenicity score (mean of the skin reactivities for each allergen) will be compared between each age groups. The impact of tabagism, gender, BMI and residential area on the allergic reactivity will also be assessed in the overall population and within each age group.

The main objective is to evaluate the effect of age on the skin test positivity. The secondary objective is to highlight the environmental factors that have an impact on allergic diseases.


Condition or disease Intervention/treatment
Allergy Other: Retrospective analysis of patient files

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Study Type : Observational
Actual Enrollment : 1400 participants
Observational Model: Case-Only
Time Perspective: Retrospective
Official Title: Impact of Age on the Prevalence of Allergic Sensitization
Study Start Date : May 2016
Actual Primary Completion Date : September 2016
Actual Study Completion Date : September 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Allergy

Group/Cohort Intervention/treatment
Immuno-allergology patients
Patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital, who received an allergy assessment between 01/01/2015 and 31/12/2015. At least 1400 dermis will be analyzed. The allergens tested include: dermatophagoides pteronyssinus (DEPT), dermatophagoides farinae (DPF), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel.
Other: Retrospective analysis of patient files
The results of the allergen skin tests will be encoded as the edema diameter. The allergenicity score (mean of the skin reactivities for each allergen) will be compared between each age groups. The impact of tabagism, gender, BMI and residential area on the allergic reactivity will also be assessed in the overall population and within each age group.




Primary Outcome Measures :
  1. Allergenicity score [ Time Frame: one year (01/01/2015 to 31/12/2015) ]
    Mean of the skin reactivities for each allergen. The results of the allergen skin tests are encoded as the edema diameter. Scores will be compared between the different age groups.


Secondary Outcome Measures :
  1. Smoking status [ Time Frame: one year (01/01/2015 to 31/12/2015) ]
    Effect of the smoking/non smoking status on the allergic reactivity, analysed in the hole group and in the different age groups.

  2. Geographic localisation [ Time Frame: one year (01/01/2015 to 31/12/2015) ]
    Effect of the area of residence on the allergic reactivity, analysed in the hole group and in the different age groups.

  3. Sex [ Time Frame: one year (01/01/2015 to 31/12/2015) ]
    Gender effect on the allergic reactivity, analysed in the hole group and in the different age groups.

  4. Body Mass Index [ Time Frame: one year (01/01/2015 to 31/12/2015) ]
    Effect of the body mass index on the allergic reactivity, analysed in the hole group and in the different age groups.



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital, who received an allergy assessment between 01/01/2015 and 31/12/2015.
Criteria

Inclusion Criteria:

  • All patients followed within the Immuno-Allergology Service of the CHU Brugmann Hospital
  • Who received an allergy assessment between 01/01/2015 and 31/12/2015. The allergens tested include: dermatophagoides pteronyssinus (DEPT), dermatophagoides farinae (DPF), blomia, cat, dog, cockroach, orchardgrass, timothy grass, alder, hazel,birch, olive tree, cypress, ash, latex, aspergillus, alternaria, cladosporium, peanut, hazel.

Exclusion Criteria:

  • Negative histamine patients

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02730520


Locations
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Belgium
CHU Brugmann
Brussels, Belgium, 1020
Sponsors and Collaborators
Brugmann University Hospital
Investigators
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Principal Investigator: Olivier Michel, MD CHU Brugmann

Publications:
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Responsible Party: Olivier Michel, Head of clinic, Brugmann University Hospital
ClinicalTrials.gov Identifier: NCT02730520     History of Changes
Other Study ID Numbers: CHUB-Age-Allergy
First Posted: April 6, 2016    Key Record Dates
Last Update Posted: September 12, 2016
Last Verified: September 2016

Keywords provided by Olivier Michel, Brugmann University Hospital:
respiratory disease
allergen sensitization
aging
skin tests
air allergens