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MRI Biomarkers and Exercise

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ClinicalTrials.gov Identifier: NCT02729428
Recruitment Status : Completed
First Posted : April 6, 2016
Last Update Posted : December 9, 2019
Sponsor:
Collaborator:
National Institutes of Health (NIH)
Information provided by (Responsible Party):
University of Wisconsin, Madison

Brief Summary:
The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.

Condition or disease Intervention/treatment
Cerebrovascular Circulation Device: MRI

Detailed Description:

Normal aging reduces cerebral blood flow, brain volume, and cognitive function, thereby increasing the risk of dementia or Alzheimer's disease. Aging is associated with increased white matter hyperintensities (WMH) and appears to alter functional connectivity within the brain both of which associated with cognitive function (references). Observational studies suggest that regular physical activity is associated with improved cognitive function and higher cerebral blood flow 1,2. However, it is unknown if aging or exercise training status alters the structural and functional biomarkers that are predictive of cognitive decline. Thus, the overall goal of this project is to examine the age-related and exercise training status-related differences in structural and functional changes in the brain, detected by magnetic resonance (MR) imaging.

  1. To determine if white matter hyperintensities on MRI scans of the brain are altered by aging and exercise training status.
  2. To determine the interaction of aging and habitual physical activity on functional connectivity in the brain.

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Study Type : Observational
Actual Enrollment : 71 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans
Actual Study Start Date : April 2016
Actual Primary Completion Date : April 2019
Actual Study Completion Date : April 2019

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Exercise trained young adults
Exercise trained young adults between the age of 18-35 years.
Device: MRI
Participants will undergo an MRI scan

Sedentary young adults
Sedentary young adults between the age of 18-35 years.
Device: MRI
Participants will undergo an MRI scan

Exercise trained older adults
Exercise trained older adults between the age of 55-75 years.
Device: MRI
Participants will undergo an MRI scan

Sedentary older adults
Sedentary older adults between the age of 55-75 years.
Device: MRI
Participants will undergo an MRI scan




Primary Outcome Measures :
  1. White Matter Hyperintensity Volume [ Time Frame: 60 minutes ]
    Utilize an MRI to measure brain volume when participant is at rest


Secondary Outcome Measures :
  1. Default Mode Network Connectivity [ Time Frame: 60 minutes ]
    Utilize an MRI to measure functional connectivity in the brain when participant is at rest

  2. Middle Cerebral Artery Blood Flow Scan [ Time Frame: 60 minutes ]
    Utilize an MRI to measure middle cerebral artery blood flow in the brain when the participant is at rest



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects for this study will include healthy young adults (18-35 years old), sedentary older adults (55-75 years old), and healthy exercise trained older adults (55-75 years old). Both men and women will be eligible to participate in this study.
Criteria

Inclusion Criteria:

  • Between 18-35 or 55-75
  • Body mass index <34 kg/m2
  • Physically active (exercise more than 3 times per week for at least 30 min) or sedentary (no formal exercise over 1 hour per week)

Exclusion Criteria:

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02729428


Locations
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United States, Wisconsin
Gymnasium-Natatorium
Madison, Wisconsin, United States, 53716
Sponsors and Collaborators
University of Wisconsin, Madison
National Institutes of Health (NIH)
Investigators
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Principal Investigator: Jill N Barnes, PhD University of Wisconsin, Madison
Publications:

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Responsible Party: University of Wisconsin, Madison
ClinicalTrials.gov Identifier: NCT02729428    
Other Study ID Numbers: 2015-1611
CVR-AAA4385 ( Other Identifier: UW-Madison Study Staff )
A176000 ( Other Identifier: UW, Madison )
EDUC/KINESIOLOGY/KINESIO ( Other Identifier: UW, Madison )
First Posted: April 6, 2016    Key Record Dates
Last Update Posted: December 9, 2019
Last Verified: December 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by University of Wisconsin, Madison:
Aging
White Matter Hyperintensity Volume
Default Mode Network Connectivity
Cognitive Function
Cardiorespiratory Fitness
Magnetic Resonance Imaging