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Relationship Between Circulating Tumor Stem Cells and the Clinical Pathology

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ClinicalTrials.gov Identifier: NCT02727673
Recruitment Status : Completed
First Posted : April 4, 2016
Last Update Posted : April 4, 2016
Sponsor:
Information provided by (Responsible Party):
ShenFeng, Eastern Hepatobiliary Surgery Hospital

Brief Summary:
The aim of this study is to establish a platform of detecting and sorting circulating tumor stem cells from peripheral blood in HCC patients; to investigate the relationship between circulating tumor stem cells and their effects on postoperative recurrence and metastasis, in order to provide a new therapeutic target for hepatocellular carcinoma treatment.

Condition or disease
Cancer Stem Cells Postoperative Recurrence and Metastasis Hepatocellular Carcinoma

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Study Type : Observational
Actual Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Randomized Trial on the Relationship Between Circulating Tumor Stem Cells and the Clinical Pathology
Study Start Date : December 2012
Actual Primary Completion Date : August 2014
Actual Study Completion Date : December 2014

Group/Cohort
healthy volunteers
matched group
hepatitis cirrhosis
negative group
hepatocellular carcinoma
patients with primary HCC



Primary Outcome Measures :
  1. the overall survival rate of each group [ Time Frame: 3 years ]


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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
250 healthy volunteers, 250 patients with hepatitis cirrhosis, 500 patients with HCC;
Criteria

Inclusion Criteria:

  1. Male or female patients > 18 years and <=70 years of age;
  2. No dysfunction in major organs; Blood routine, kidney function, cardiac function and lung function are basically normal.
  3. Patients who can understand this trial and have signed information consent

Exclusion Criteria:

  1. Reject to attend;
  2. Impossible to come to our hospital for physical examination regularly;
  3. Patients with other diseases which may affect the treatment mentioned

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02727673


Locations
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China, Shanghai
Eastern hepatobilliary surgery hospital
Shanghai, Shanghai, China, 200438
Sponsors and Collaborators
Eastern Hepatobiliary Surgery Hospital

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Responsible Party: ShenFeng, vice president of the Eastern Hepatobiliary Surgery Hospital, Eastern Hepatobiliary Surgery Hospital
ClinicalTrials.gov Identifier: NCT02727673     History of Changes
Other Study ID Numbers: ZD201200102-P1
First Posted: April 4, 2016    Key Record Dates
Last Update Posted: April 4, 2016
Last Verified: March 2016

Keywords provided by ShenFeng, Eastern Hepatobiliary Surgery Hospital:
cancer stem cells

Additional relevant MeSH terms:
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Liver Neoplasms
Liver Diseases
Pathologic Processes
Carcinoma, Hepatocellular
Recurrence
Adenocarcinoma
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases
Disease Attributes